Anti-inflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride

被引：40
|
作者：
Suleyman, H
Gul, HI [1 ]
Asoglu, M
机构：
[1] Ataturk Univ, Fac Pharm, Dept Pharmaceut Chem, TR-25240 Erzurum, Turkey
[2] Ataturk Univ, Fac Med, Dept Pharmacol, TR-25240 Erzurum, Turkey
来源：
PHARMACOLOGICAL RESEARCH | 2003年 / 47卷 / 06期
关键词：
anti-inflammatory activity; hyaluronidase activity; indomethacin; Mannich base; piperodinol; rat;
D O I：
10.1016/S1043-6618(03)00015-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In our study. the effects of the compound 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride (C1) and also an anti-inflammatory drug, indomethacin, tested by carrageenan-induced paw edema and cotton pellet granuloma tests, for their effects on acute and chronic phases If inflammation. respectively. Their effects on vascular permeability were also tested by hyaluronidase-induced capillary permeability. C1 decreased the carrageenan-induced paw edema 61.98, 80.84, and 90.32% at 50, 100, and 200 mg kg(-1) doses, respectively, while this decrease was 89.93% by indomethacin at 20 mg kg(-1) dose. Antiproliferative effects of C1 at 100 mg kg(-1) and indomethacinin at 20 mg kg(-1) doses were 46.1 and 43.1%. respectively, in cotton pellet test. C1 and indomethacin both significantly inhibited the hyaluronidase-induced increase in capillary permeability. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：471 / 475
页数：5
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