The Protective Effect of Vitamin C Against Toxicity Induced by Lead-Acetate on Liver and Spleen in Swiss Albino Mice

被引：0
|
作者：
Aldahmash, Badr Abdullah [1 ]
El-Nager, Doaa M. [2 ]
机构：
[1] King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia
[2] Salman Univ, Fac Sci & Humanity, Hotat Bani Tamim, Al Kharj, Saudi Arabia
来源：
PAKISTAN JOURNAL OF ZOOLOGY | 2014年 / 46卷 / 05期
关键词：
Mice-vitamin C; lead; liver; spleen; OXIDATIVE STRESS; HEPATOTOXICITY; EXPOSURE;
D O I：
暂无
中图分类号：
Q95 [动物学];
学科分类号：
071002 ;
摘要：
The present study was carried out to investigate the protective effect of vitamin C as antioxidant to reduce hepatotoxicity and spleen toxicity induced by lead. Lead acetate administered at 20 mg/kg intake caused severe alterations in liver and spleen manifested by hepatocytes degeneration and leucocytes infiltration and fibrosis in liver, ill-defined architecture and large macrophages in the spleen. Vitamin C administered at 500 mg/kg of vitamin C one hour prior to lead reduced hepatotoxicity but did not affect liver fibrosis. Moreover, Vitamin C reduced the toxicity in spleen characterized by well-defined spleen architecture.
引用
收藏
页码：1425 / 1431
页数：7
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