Racemization Free Protocol for the Synthesis of N-tert-Butanesulfinyl Ketimines

被引：23
|
作者：
Datta, Gopal K. [2 ]
Ellman, Jonathan A. [1 ]
机构：
[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA
[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 18期
基金：
美国国家科学基金会;
关键词：
ASYMMETRIC-SYNTHESIS; DIRECT CONDENSATION; FACILE SYNTHESIS; SULFINIMINES; ALDEHYDES; SULFINAMIDES; IMINES; ALDIMINES; AMINES;
D O I：
10.1021/jo1011625
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general and robust racemization-free protocol for the synthesis of a variety of N-tert-butanesulfinyl ketimines is reported. Reaction progress was monitored by H-1 NMR using the nonperturbing internal standard diglyme, and ketimines were formed in good to high yields in either THF or CPME (cyclopentyl methyl ether) as solvent with heating to reflux.
引用
收藏
页码：6283 / 6285
页数：3
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