Identification of target genes of microRNAs in retinoic acid-induced neuronal differentiation

被引：4
|
作者：
Kawasaki, H
Taira, K
机构：
[1] Univ Tokyo, Dept Chem & Biotechnol, Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan
[2] Natl Inst Adv Ind Sci & Technol, Gene Funct Res Ctr, Tsukuba, Ibaraki 3058562, Japan
来源：
PURE AND APPLIED CHEMISTRY | 2005年 / 77卷 / 01期
关键词：
D O I：
10.1351/pac200577010313
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
MicroRNAs (rniRNAs) are phylogenetically widespread, small noncoding RNAs of 18-25 nucleoticles in length, and are expressed in animals and plants. These small RNAs can regulate gene expression at the translational level through interactions with their target messenger RNAs, and have a role in the development of Caenorhabditis elegans, plants, and mammals. Although more than 200 miRNAs have been found in mammals, it is not easy to identify their targets. We investigated the target genes of miRNAs and analyzed the function of these miRNAs during retinoic acid (RA)-induced neuronal differentiation.
引用
收藏
页码：313 / 318
页数：6
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