Synthesis of New 2-N-Substituted Amino-5-aryl-1,3-thiazoles as Antitumor Agents

被引：0

作者：

Elsayed, Elsherbiny Hamdy ^{[1
]}

Moustafa, Amal Y. ^{[1
]}

El-Ata, Sara A. A. ^{[1
]}

机构：

[1] Port Said Univ, Chem Dept, Fac Sci, Port Said, Egypt

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2018年 / 37卷 / 08期

关键词：

cytotoxicity; HepG-2; MCF-7; thiazole; ALPHA-AMINOPHOSPHONATES;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new 5-aryl-2-N-substituted thiazole derivatives 3a, b were synthesized via the cyclization of thiosemicarbazone 2 with viaries alpha-bromomethyl aryl ketones. Acetylation and alkylation of thiazole derivatives 3a, b with acetic anhydride and ethyl chloroacetate gave the corresponding N-acetyl and N-alkyl derivatives 4 and 5. The structures of the synthesized 1,3- thiazole derivatives 3, 4 and 5 were confirmed by IR, H-1, C-13-NMR, MS and elemental analysis. All the synthesized thiazole derivatives and carbazone were tested for their cytotoxicity against two different cancer cell lines MCF-7 and HepG-2. Some of these compounds showed good cytotoxicity.

引用

页码：1594 / 1601

页数：8

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