Synthesis of New 2-N-Substituted Amino-5-aryl-1,3-thiazoles as Antitumor Agents

A new 5-aryl-2-N-substituted thiazole derivatives 3a, b were synthesized via the cyclization of thiosemicarbazone 2 with viaries alpha-bromomethyl aryl ketones. Acetylation and alkylation of thiazole derivatives 3a, b with acetic anhydride and ethyl chloroacetate gave the corresponding N-acetyl and N-alkyl derivatives 4 and 5. The structures of the synthesized 1,3- thiazole derivatives 3, 4 and 5 were confirmed by IR, H-1, C-13-NMR, MS and elemental analysis. All the synthesized thiazole derivatives and carbazone were tested for their cytotoxicity against two different cancer cell lines MCF-7 and HepG-2. Some of these compounds showed good cytotoxicity.