Picornavirus Identified in Alzheimer's Disease Brains: A Pathogenic Path?

被引：9

作者：

Niklasson, Bo ^{[1
]}

Lindquist, Lars ^{[2
]}

Klitz, William ^{[3
]}

Bank, Netherlands Brain ^{[4
]}

Englund, Elisabet ^{[5
]}

机构：

[1] Jordbro Primary Hlth Care Ctr, S-13764 Stockholm, Sweden

[2] Karolinska Inst, Dept Med Huddinge, Div Infect Dis, Stockholm, Sweden

[3] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA

[4] Netherlands Inst Neurosci, Netherlands Brain Bank, Amsterdam, Netherlands

[5] Lund Univ, Dept Clin Sci, Div Pathol, Lund, Sweden

来源：

JOURNAL OF ALZHEIMERS DISEASE REPORTS | 2020年 / 4卷 / 01期

关键词：

Alzheimer's disease; immunohistochemistry; Ljungan virus; neurodegenerative disease; picornavirus; ZOONOTIC LJUNGAN VIRUS; IMMUNOHISTOCHEMISTRY; DEMENTIA; PROTEIN; SYSTEM; DEATH; TAU;

D O I：

10.3233/ADR-200174

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated formalin-fixed postmortem brain tissue from the hippocampus region of 18 AD cases and 11 age-matched controls using a polyclonal antibody against Ljungan virus (LV) capsid protein 1. Evidence of a LV antigen was found in all AD cases but in none of the control specimens (p < 0.0001). The antibodies reacted with neurons and astrocytes and also showed distinct positive reaction in the amyloid/neuritic plaques. The possible role of an incompletely characterized picornavirus as the etiologic agent in AD open up the possibility of treatment with antiviral therapy directed against picornaviruses. The positive result of such treatment in a small number of patients is presented separately back to back to this report.

引用

页码：141 / 146

页数：6

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