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Brain Tumors in Children
被引:48
|作者:
Cohen, Alan R.
[1
,2
]
机构:
[1] Johns Hopkins Univ, Dept Neurosurg, Sch Med, Baltimore, MD USA
[2] Johns Hopkins Univ, Sch Med, Phipps Bldg,Rm 556,600 N Wolfe St, Baltimore, MD 21287 USA
来源:
关键词:
CENTRAL-NERVOUS-SYSTEM;
MAPK PATHWAY ACTIVATION;
HIGH-GRADE GLIOMAS;
MOLECULAR SUBGROUPS;
PROGNOSTIC-FACTORS;
LONG-TERM;
MEDULLOBLASTOMA;
CHILDHOOD;
MUTATIONS;
CLASSIFICATION;
D O I:
10.1056/NEJMra2116344
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Brain Tumors in ChildrenChildhood brain tumors were previously classified by histologic appearance and location. A new classification includes genetic changes, which have prognostic significance and may lead to therapeutic targets. This review focuses on pediatric gliomas, ependymomas, and medulloblastomas.
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页码:1922 / 1931
页数:10
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