COMT haplotypes, catecholamine metabolites in plasma and clinical response in schizophrenic and bipolar patients

被引：7

作者：

Zumarraga, Mercedes ^{[1
]}

Arrue, Aurora ^{[1
]}

Basterreche, Nieves ^{[2
,3
]}

Macias, Isabel ^{[4
]}

Catalan, Ana ^{[5
]}

Madrazo, Arantza ^{[5
]}

Bustamante, Sonia ^{[5
]}

Zamalloa, Maria I. ^{[1
]}

Erkoreka, Leire ^{[3
,6
]}

Gordo, Estibaliz ^{[2
]}

Arnaiz, Ainara ^{[2
]}

Olivas, Olga ^{[7
]}

Arroita, Ariane ^{[6
]}

Marin, Elena ^{[8
]}

Gonzalez-Torres, Miguel A. ^{[3
,5
]}

机构：

[1] Osakidetza, Hosp Zamudio, Red Salud Mental Bizkaia, Dept Invest Neuroquim, Arteaga Auzoa 45, Zamudio 48170, Bizkaia, Spain

[2] Osakidetza, Hosp Zamudio, Red Salud Mental Bizkaia, Unidad Hospitalizac Corta Estancia, Arteaga Auzoa 45, Zamudio 48170, Bizkaia, Spain

[3] Univ Basque Country, Fac Med, Dept Psiquiatria & Psicol Med, Barrio Sarriena S-N, Leioa 48940, Bizkaia, Spain

[4] Osakidetza, Red Salud Mental Bizkaia, Hosp Zamudio, Unidad Salud Laboral, Arteaga Auzoa 45, Zamudio 48170, Bizkaia, Spain

[5] Osakidetza, Hosp Basurto, Serv Psiquiatria, Ave Montevideo 18, Bilbao 48013, Spain

[6] Osakidetza, Red Salud Mental Bizkaia, Ctr Salud Mental Barakaldo, La Felicidad 9,3, Baracaldo 48901, Bizkaia, Spain

[7] Osakidetza, Red Salud Mental Bizkaia, Ctr Salud Mental Gernika, San Juan 1, Gernika 48300, Bizkaia, Spain

[8] Hosp Psiquiatr Bermeo, Tonpoi Bidea S-N, Bermeo 48370, Bizkaia, Spain

来源：

PHARMACOGENOMICS | 2016年 / 17卷 / 08期

关键词：

antipsychotics; bipolar disorder; COMT; haplotypes; plasma metabolites; schizophrenia; symptomatology; O-METHYLTRANSFERASE; HOMOVANILLIC-ACID; HUMAN BRAIN; FUNCTIONAL POLYMORPHISM; NONAFFECTIVE PSYCHOSIS; NEGATIVE SYMPTOMS; GENETIC-VARIATION; ETIOLOGIC FACTOR; MOOD DISORDERS; ASSOCIATION;

D O I：

10.2217/pgs-2016-0022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: We examined the association of COMT haplotypes and plasma metabolites of catecholamines in relation to the clinical response to antipsychotics in schizophrenic and bipolar patients. Patients & methods: We studied 165 patients before and after four weeks of treatment, and 163 healthy controls. We assessed four COMT haplotypes and the plasma concentrations of HVA, DOPAC and MHPG. Results: Bipolar patients: haplotypes are associated with age at onset and clinical evolution. In schizophrenic patients, an haplotype previously associated with increased risk, is related to better response of negative symptoms. Conclusion: Haplotypes would be good indicators of the clinical status and the treatment response in bipolar and schizophrenic patients. Larger studies are required to elucidate the clinical usefulness of these findings.

引用

页码：837 / 851

页数：15

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