Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins

被引：31

作者：

Sarkar, Rahul ^{[1
]}

Mitra, Sankash ^{[1
]}

Mukherjee, Santanu ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

CHEMICAL SCIENCE | 2018年 / 9卷 / 26期

关键词：

ASYMMETRIC UMPOLUNG ALLYLATION; SUBSTITUTION-REACTIONS; DECONJUGATED BUTENOLIDES; MICHAEL ADDITION; DEAROMATIZATION REACTION; VICINAL STEREOCENTERS; SYNERGISTIC IRIDIUM; CONJUGATE ADDITION; ACID DERIVATIVES; GAMMA-ALLYLATION;

D O I：

10.1039/c8sc02041h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first iridium-catalyzed enantioselective vinylogous allylic alkylation of coumarins is presented. Using easily accessible linear allylic carbonates as the allylic electrophile, this reaction installs unfunctionalized allyl groups at the -position of 4-methylcoumarins in an exclusively branched-selective manner generally in high yields with an excellent level of enantioselectivity (up to 99:1 er).

引用

页码：5767 / 5772

页数：6

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