Cytokines and autoimmunity

被引：497
|
作者：
O'Shea, JJ
Ma, A
Lipsky, P
机构：
[1] NIAMSD, Lymphocyte Cell Biol Sect, Arthritis & Rheumat Branch, NIH, Bethesda, MD 20892 USA
[2] Univ Chicago, Dept Med, Chicago, IL 60637 USA
[3] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 01期
关键词：
D O I：
10.1038/nri702
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cytokines have crucial functions in the development, differentiation and regulation of immune cells. As a result, dysregulation of cytokine production or action is thought to have a central role in the development of autoimmunity and autoimmune disease. Some cytokines, such as interleukin-2, tumour-necrosis factor and interferons - ostensibly, the 'bad guys' in terms of disease pathogenesis - are well known for the promotion of immune and inflammatory responses. However, these cytokines also have crucial immunosuppressive functions and so, paradoxically, can also be 'good guys'. The balance between the pro-inflammatory and immunosuppressive functions of these well-known cytokines and the implications for the pathogenesis of autoimmune disease is the focus of this review.
引用
收藏
页码：37 / 45
页数：9
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