Synthesis of Folate-Modified, Polyethylene Glycol-Functionalized Gold Nanoparticles for Targeted Drug Delivery

被引：22
|
作者：
Asadishad, B. [2 ]
Vosoughi, M. [2 ,3 ]
Alamzadeh, I. [1 ,2 ]
Tavakoli, A. [2 ]
机构：
[1] Sharif Univ Technol, Biochem & Bioenvironm Res Ctr, Tehran 113656891, Iran
[2] Sharif Univ Technol, Dept Chem & Petr Engn, Tehran 113656891, Iran
[3] Sharif Univ Technol, Inst Nanosci, Tehran 113656891, Iran
来源：
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2010年 / 31卷 / 04期
关键词：
Doxorubicin; folic acid; gold nanoparticles; lysine; polyethylene glycol (peg); MAGNETITE NANOPARTICLES; DOXORUBICIN; RELEASE; CANCER; CELLS; CONJUGATE; COPOLYMER; MICELLES; THERAPY; POLYMER;
D O I：
10.1080/01932690903213113
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The chemical synthesis and in vitro drug delivery response of folate-modified, polyethylene glycol-functionalized gold nanoparticles were studied. Lysine-capped gold nanoparticles were first prepared. Subsequently, the widely used anticancer agent doxorubicin (DOX) was successfully attached to the surface of folate-modified, polyethylene glycol-functionalized gold nanoparticles. Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to confirm the functionalization and conjugation steps in the chemical synthesis. The DOX-loading efficiency determined by UV-vis spectrometer was 80%. Drug release experiments displayed a controlled-release behavior that most of the conjugated doxorubicin was released within the first 12 hours.
引用
收藏
页码：492 / 500
页数：9
相关论文
共 50 条
  • [31] Dextran-coated superparamagnetic nanoparticles modified with folate for targeted drug delivery of camptothecin
    Al-Musawi, Sharafaldin (dr.sharaf@biotech.uoqasim.edu.iq); Sulaiman, Ghassan M. (gmsbiotech@hotmail.com), 1600, IOP Publishing Ltd (11):
  • [32] Enhancement in the therapeutic efficacy of thymoquinone by its delivery through polypropylene glycol-functionalized silver nanoparticles
    Raja, Daim Asif
    Bano, Amber
    Zehra, Moatter
    Vohra, Ismail
    Ahmed, Shakil
    Ahmed, Ayaz
    Bhanger, Muhammad Iqbal
    Malik, Muhammad Imran
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2024, 695
  • [33] Mechanisms facilitating the uptake of carboxyl-polythene glycol-functionalized gold nanoparticles into multicellular spheroids
    Fobian, Seth-Frerich
    Petzer, Melissa
    Vetten, Melissa
    Steenkamp, Vanessa
    Gulumian, Mary
    Cordier, Werner
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2022, 74 (09) : 1282 - 1295
  • [34] Novel approaches for posterior segment ocular drug delivery with folate-modified liposomal formulation
    Toshiki Hayashi
    Risako Onodera
    Kohei Tahara
    Hirofumi Takeuchi
    AsianJournalofPharmaceuticalSciences, 2016, 11 (01) : 201 - 202
  • [35] Surface Functionalized Gold Nanoparticles for Drug Delivery
    Cheng, Jinping
    Gu, Yan-Juan
    Cheng, Shuk Han
    Wong, Wing-Tak
    JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2013, 9 (08) : 1362 - 1369
  • [36] Functionalized gold nanoparticles for drug delivery applications
    Thambiraj, S.
    Hema, S.
    Shankaran, D. Ravi
    MATERIALS TODAY-PROCEEDINGS, 2018, 5 (08) : 16763 - 16773
  • [37] Functionalized Folate-Modified Graphene Oxide/PEI siRNA Nanocomplexes for Targeted Ovarian Cancer Gene Therapy
    Yunfei Wang
    Guoping Sun
    Yingying Gong
    Yuying Zhang
    Xiaofei Liang
    Linqing Yang
    Nanoscale Research Letters, 15
  • [38] Folate-conjugated hydrophobicity modified glycol chitosan nanoparticles for targeted delivery of methotrexate in rheumatoid arthritis
    Wu, Zhongqing
    Xu, Kanna
    Min, Jikang
    Chen, Minchang
    Shen, Liping
    Xu, Jianxue
    Jiang, Qi
    Han, Guohong
    Pan, Le
    Li, Haidong
    JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS, 2020, 18
  • [39] Investigation of Folate-Functionalized Magnetic-Gold Nanoparticles Based Targeted Drug Delivery for Liver: In Vitro, In Vivo and Docking Studies
    Alnasraui, Ali Hussein F.
    Joe, I. Hubert
    Al-Musawi, Sharafaldin
    ACS BIOMATERIALS SCIENCE & ENGINEERING, 2024, 10 (10): : 6299 - 6313
  • [40] Folate-Targeted Polyethylene Glycol-Modified Photosensitizers for Photodynamic Therapy
    Liu, Qian
    Wang, Jin
    Li, Shuang
    Li, Guojie
    Chen, Qingle
    Hong, Zhangyong
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 108 (06) : 2102 - 2111
12345