A novel and practical synthesis of 3-unsubstituted indolizines

被引：2
|
作者：
Zhang, LD
Liang, F
Sun, LZ
Hu, YF [1 ]
Hu, HW
机构：
[1] Nanjing Univ, Dept Chem, Nanjing 210093, Peoples R China
[2] Nanjing Univ, Inst Coordinat Chem, Nanjing 210093, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2000年 / 12期
关键词：
cycloadditions; dehydrogenation; manganese dioxide; heterocycles;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and practical procedure for the preparation of 3-unsubstituted indolizines by 1,3-dipolar cycloaddition was developed. The requisite pyridinium N-methylides were generated simply from the corresponding N-(carboxymethyl)pyridinium halides. In the presence of MnO2, electron-deficient alkenes, instead of alkynes or vinyl bromides, were used successfully as dipolarophiles. This general method features cheap reagents, simple workup procedure and gives the products in moderate to high yields (57-92%).
引用
收藏
页码：1733 / 1737
页数：5
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