Click Inspired Synthesis of 1,2,3-Triazole-linked 1,3,4-Oxadiazole Glycoconjugates

被引：6

作者：

Kushwaha, Divya ^{[1
]}

Tiwari, Vinod K. ^{[1
]}

机构：

[1] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 04期

关键词：

GLYCOGEN-PHOSPHORYLASE; CARBOHYDRATE-CHEMISTRY; EFFICIENT SYNTHESIS; TERMINAL ALKYNES; FACILE SYNTHESIS; INHIBITORS; DERIVATIVES; POTENT; DISCOVERY; BIOLOGY;

D O I：

10.1002/jhet.2845

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The glycoconjugation of biologically privileged 1,3,4-oxadiazole scaffold is described via Cu(I)-catalyzed azide-alkyne cycloaddition. A series of glycosyl alkynes 1b-i, obtained from various commercial sugars, were treated with azide functionalized 1,3,4-oxadiazole using click chemistry to access triazole-linked glycosylated 1,3,4-oxadiazoles 10b-i in good yields. The structure of the developed glycoconjugates has been ascertained by extensive spectroscopic analysis (H-1 &C-13 NMR, IR, and MS).

引用

页码：2454 / 2462

页数：9

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