DISCOVERY OF A NOVEL AND POTENT CHOLESTEROL ABSORPTION INHIBITOR AS PROMISING ORALLY ACTIVE LIPID LOWERING DRUG

被引:0
|
作者
Kanou, M. [1 ]
Nishiwaki, Y. [2 ]
Nakano, A. [2 ]
Yamanaka, Y. [2 ]
机构
[1] Teijin Pharma Ltd, Pharmaceut Dev Res Labs, Tokyo, Japan
[2] Teijin Pharma Ltd, Pharmaceut Discovery Res Labs, Tokyo, Japan
关键词
D O I
10.1016/S1567-5688(10)70360-3
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
P293
引用
收藏
页码:79 / 79
页数:1
相关论文
共 50 条
  • [41] Discovery of a structurally novel, drug-like and potent inhibitor of peptidylarginine deiminase
    Ferretti, Patrizia
    Pong, Kin U.
    Vagaska, Barbora
    Merchant, Rohan
    Matthews, Christopher J.
    Marson, Charles M.
    MEDCHEMCOMM, 2013, 4 (07) : 1109 - 1113
  • [42] A potent and orally active HIV-1 integrase inhibitor
    Egbertson, Melissa S.
    Moritz, H. Marie
    Melamed, Jeffrey Y.
    Han, Wei
    Perlow, Debra S.
    Kuo, Michelle S.
    Embrey, Mark
    Vacca, Joseph P.
    Zrada, Matthew M.
    Cortes, Amanda R.
    Wallace, Audrey
    Leonard, Yvonne
    Hazuda, Daria J.
    Miller, Michael D.
    Felock, Peter J.
    Stillmock, Kara A.
    Witmer, Marc V.
    Schleif, William
    Gabryelski, Lori J.
    Moyer, Gregory
    Ellis, Joan D.
    Jin, Lixia
    Xu, Wei
    Braun, Matthew P.
    Kassahun, Kellem
    Tsou, Nancy N.
    Young, Steven D.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (05) : 1392 - 1398
  • [43] Identification of a novel boronic acid as a potent, selective, and orally active hormone sensitive lipase inhibitor
    Ogiyama, Tomoko
    Yamaguchi, Mitsuhiro
    Kurikawa, Nobuya
    Honzumi, Shoko
    Yamamoto, Yuka
    Sugiyama, Daisuke
    Inoue, Shinichi
    BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (16) : 3801 - 3807
  • [44] Pharmacological profile of SB939, a novel, potent and orally active histone deacetylase inhibitor
    Sangthongpitag, K.
    Wu, X.
    Khng, H.
    Goh, S.
    Ng, P.
    Hu, C.
    Bonday, Z.
    Wang, H.
    Wood, J.
    Entzeroth, M.
    EJC SUPPLEMENTS, 2006, 4 (12): : 52 - 52
  • [45] Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened
    Munchhof, Michael J.
    Li, Qifang
    Shavnya, Andrei
    Borzillo, Gary V.
    Boyden, Tracey L.
    Jones, Christopher S.
    LaGreca, Susan D.
    Martinez-Alsina, Luis
    Patel, Nandini
    Pelletier, Kathleen
    Reiter, Larry A.
    Robbins, Michael D.
    Tkalcevic, George T.
    ACS MEDICINAL CHEMISTRY LETTERS, 2012, 3 (02): : 106 - 111
  • [46] Blood pressure lowering with SPP100, a novel orally active renin inhibitor - A pilot study
    Stanton, AV
    Mann, J
    Jensen, C
    O'Brien, ET
    HYPERTENSION, 2001, 38 (03) : 526 - 526
  • [47] Discovery and Evaluation of Pyrazolo[3,4-d]pyridazinone as a Potent and Orally Active Irreversible BTK Inhibitor
    Zhang, Xuejun
    Sheng, Xijun
    Shen, Jie
    Zhang, Shoubo
    Sun, Wenjie
    Shen, Chunli
    Li, Yi
    Wang, Jun
    Lv, Huqiang
    Cui, Minghui
    Zhu, Yuchuan
    Huang, Lei
    Hao, Dongling
    Qi, Zhibo
    Sun, Guanglong
    Mao, Weifeng
    Pan, Yan
    Shen, Liang
    Li, Xin
    Hu, Guoping
    Gong, Zhen
    Han, Shuhua
    Li, Jian
    Chen, Shuhui
    Tu, Ronghua
    Wang, Xuehai
    Wu, Chengde
    ACS MEDICINAL CHEMISTRY LETTERS, 2020, 11 (10): : 1863 - 1868
  • [48] Discovery of Sch 444877, a potent, selective and orally active cyclic guanine PDE5 inhibitor.
    Wang, YG
    Chackalamannil, S
    Stamford, A
    Boyle, CD
    Hu, ZY
    Lankin, C
    Clader, J
    Xu, R
    Asberom, T
    Pissarnitski, D
    Greenlee, W
    Kurowski, S
    Vemulapalli, S
    Palamanda, J
    Chintala, M
    Wu, P
    Myers, J
    Wang, P
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U69 - U69
  • [49] Discovery of a Highly Potent, Orally Active Mitosis/Angiogenesis Inhibitor R1530 for the Treatment of Solid Tumors
    Liu, Jin-Jun
    Higgins, Brian
    Ju, Grace
    Kolinsky, Kenneth
    Luk, Kin-Chun
    Packman, Kathryn
    Pizzolato, Giacomo
    Ren, Yi
    Thakkar, Kshitij
    Tovar, Christian
    Zhang, Zhuming
    Woykulich, Peter M.
    ACS MEDICINAL CHEMISTRY LETTERS, 2013, 4 (02): : 259 - 263
  • [50] Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor
    Bharate, Sandip B.
    Kumar, Vikas
    Jain, Shreyans K.
    Mintoo, Mubashir J.
    Guru, Santosh K.
    Nuthakki, Vijay K.
    Sharma, Mohit
    Bharate, Sonali S.
    Gandhi, Sumit G.
    Mondhe, Dilip M.
    Bhushan, Shashi
    Vishwakarma, Ram A.
    JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (04) : 1664 - 1687