Shorter leukocyte telomere length is associated with higher risk of infections: a prospective study of 75,309 individuals from the general population

被引:61
|
作者
Helby, Jens [1 ,2 ,3 ]
Nordestgaard, Borge G. [1 ,2 ,3 ,4 ]
Benfield, Thomas [3 ,5 ]
Bojesen, Stig E. [1 ,2 ,3 ,4 ]
机构
[1] Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Copenhagen, Denmark
[2] Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Copenhagen, Denmark
[3] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark
[4] Copenhagen Univ Hosp, Bispebjerg & Frederiksberg Hosp, Copenhagen City Heart Study, Copenhagen, Denmark
[5] Copenhagen Univ Hosp, Dept Infect Dis, Hvidovre Hosp, Copenhagen, Denmark
关键词
COMMUNITY-ACQUIRED PNEUMONIA; REPLICATIVE SENESCENCE; CIRCULATING LEUKOCYTES; CELL TRANSPLANTATION; MORTALITY; BLOOD; SURVIVAL; DISEASE; CANCER; HOSPITALIZATION;
D O I
10.3324/haematol.2016.161943
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In the general population, older age is associated with short leukocyte telomere length and with high risk of infections. In a recent study of allogeneic hematopoietic cell transplantation for severe aplastic anemia, long donor leukocyte telomere length was associated with improved survival in the recipients. These findings suggest that leukocyte telomere length could possibly be a marker of immune competence. Therefore, we tested the hypothesis that shorter leukocyte telomere length is associated with higher risk of infectious disease hospitalization and infection-related death. Relative peripheral blood leukocyte telomere length was measured using quantitative polymerase chain reaction in 75,309 individuals from the general population and the individuals were followed for up to 23 years. During follow up, 9228 individuals were hospitalized with infections and infection-related death occurred in 1508 individuals. Shorter telomere length was associated with higher risk of any infection (hazard ratio 1.05 per standard deviation shorter leukocyte telomere length; 95% confidence interval 1.03-1.07) and pneumonia (1.07; 1.03-1.10) after adjustment for conventional infectious disease risk factors. Corresponding hazard ratios for infection-related death were 1.10 (1.04-1.16) for any infection and 1.11 (1.04-1.19) for pneumonia. Telomere length was not associated with risk of skin infection, urinary tract infection, sepsis, diarrheal disease, endocarditis, meningitis or other infections. In conclusion, our findings indicate that leukocyte telomere length may be a marker of immune competence. Further studies are needed to determine whether risk of infections in allogeneic hematopoietic cell transplantation recipients can be reduced by considering donor leukocyte telomere length when selecting donors.
引用
收藏
页码:1457 / 1465
页数:9
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