Pillar[5]arene based supramolecular prodrug micelles with pH induced aggregate behavior for intracellular drug delivery

被引：47
|
作者：
Wang, Yin [1 ]
Du, Jianwei [1 ]
Wang, Youxiang [1 ]
Jin, Qiao [1 ]
Ji, Jian [1 ]
机构：
[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 14期
基金：
中国国家自然科学基金; 高等学校博士学科点专项科研基金;
关键词：
MOLECULAR RECOGNITION; CONTROLLED-RELEASE; CELLULAR-UPTAKE; WATER; NANOPARTICLES; TUMORS; COMPLEXATION; BINDING; DESIGN;
D O I：
10.1039/c4cc09274k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel type of dual pH-responsive supramolecular prodrug micelles based on host-guest interactions of water-soluble pillar[5] arene (WP5) and methyl viologen functioned doxorubicin (MV-DOX) was prepared. It was found that the prodrug micelles could be aggregated upon acidic condition, which led to enhanced accumulation and better therapy effect.
引用
收藏
页码：2999 / 3002
页数：4
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