Gene3D: expanding the utility of domain assignments

被引：44

作者：

Lam, Su Datt ^{[1
]}

Dawson, Natalie L. ^{[1
]}

Das, Sayoni ^{[1
]}

Sillitoe, Ian ^{[1
]}

Ashford, Paul ^{[1
]}

Lee, David ^{[1
]}

Lehtinen, Sonja ^{[1
,2
]}

Orengo, Christine A. ^{[1
]}

Lees, Jonathan G. ^{[1
]}

机构：

[1] UCL, Inst Struct & Mol Biol, Div Biosci, Gower St, London WC1E 6BT, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, St Marys Campus,Norfolk Pl, London W2 1PG, England

来源：

NUCLEIC ACIDS RESEARCH | 2016年 / 44卷 / D1期

基金：

英国生物技术与生命科学研究理事会;

关键词：

PROTEIN; SUPERFAMILIES; ANNOTATIONS; DATABASE;

D O I：

10.1093/nar/gkv1231

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gene3D http://gene3d.biochem.ucl.ac.uk is a database of domain annotations of Ensembl and UniProtKB protein sequences. Domains are predicted using a library of profile HMMs representing 2737 CATH superfamilies. Gene3D has previously featured in the Database issue of NAR and here we report updates to the website and database. The current Gene3D (v14) release has expanded its domain assignments to similar to 20 000 cellular genomes and over 43 million unique protein sequences, more than doubling the number of protein sequences since our last publication. Amongst other updates, we have improved our Functional Family annotation method. We have also improved the quality and coverage of our 3D homology modelling pipeline of predicted CATH domains. Additionally, the structural models have been expanded to include an extra model organism (Drosophila melanogaster). We also document a number of additional visualization tools in the Gene3D website.

引用

页码：D404 / D409

页数：6

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