Scaling Wet Fine Grinding Processes of Organic Particles Using Stirred Media Mills

被引：10

作者：

Flach, Frederik ^{[1
]}

Breitung-Faes, Sandra ^{[1
]}

Kwade, Arno ^{[1
]}

机构：

[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Particle Technol, Volkmaroder Str 5, D-38104 Braunschweig, Germany

来源：

CHEMIE INGENIEUR TECHNIK | 2017年 / 89卷 / 08期

关键词：

Nanoparticles; Scale-up; Stirred media milling; Stress energy calculation; ACTIVE PHARMACEUTICAL INGREDIENTS; HIGH-PRESSURE HOMOGENIZATION; FORMULATION DEVELOPMENT; STRESS INTENSITY; MODEL; WEAR; DRUG; NANOSUSPENSIONS; OPTIMIZATION; MECHANISMS;

D O I：

10.1002/cite.201600148

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

This study presents an approach to scale up wet fine grinding processes of organic particles using stirred media mills. The process transfer is based on the calculation of grinding-relevant energy, which is transferred to the product by a model theory derived from mill-related values, especially geometric aspects. Its application was demonstrated by experimental work with two organic products, which were ground with different sizes and geometries of mills reaching from 20 to 900 mL grinding chamber volume under variation of process parameters.

引用

页码：1051 / 1059

页数：9

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