Synthesis of guanidine derivatives and molecular recognition

被引:6
|
作者
Qi, YX [1 ]
Gao, HX [1 ]
Yang, M [1 ]
Xia, CG [1 ]
Suo, J [1 ]
机构
[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo SYntheis & Select Oxidat, Lanzhou 730000, Peoples R China
关键词
D O I
10.1081/SCC-120017128
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Five Guanidine Derivatives bearing acyl group were synthesized by the reaction of acyl chloride with 1,1,3,3-tetramethylguanidine. Their structures were confirmed by IR, H-1-NMR, EI-MS, HRMS and elementary analysis. One of them (4a) was also characterized by X-ray. Preliminary results of interaction with phosphate-containing biomolecules and adipate showed that all of them exhibited the abilities of molecular recognition.
引用
收藏
页码:1073 / 1079
页数:7
相关论文
共 50 条
  • [1] A SYNTHESIS OF GUANIDINE DERIVATIVES
    FARRAR, WV
    JOURNAL OF THE CHEMICAL SOCIETY, 1965, (FEB): : 856 - &
  • [2] THE HISTOCHEMICAL RECOGNITION OF CERTAIN GUANIDINE DERIVATIVES
    BAKER, JR
    QUARTERLY JOURNAL OF MICROSCOPICAL SCIENCE, 1947, 88 (01): : 115 - 121
  • [3] THE SYNTHESIS OF SOME GUANIDINE DERIVATIVES
    ZMITEK, J
    JENKO, B
    KOSAK, A
    MILIVOJEVIC, D
    ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1985, 17 (4-5) : 256 - 261
  • [4] Synthesis of Guanidine Derivatives of Methylcytisine
    P. R. Petrova
    A. V. Koval’skaya
    A. N. Lobov
    I. P. Tsypysheva
    Chemistry of Natural Compounds, 2019, 55 : 1110 - 1114
  • [5] Synthesis of Guanidine Derivatives of Methylcytisine
    Petrova, P. R.
    Koval'skaya, A. V.
    Lobov, A. N.
    Tsypysheva, I. P.
    CHEMISTRY OF NATURAL COMPOUNDS, 2019, 55 (06) : 1110 - 1114
  • [6] Synthesis, molecular modeling and biological evaluation of guanidine derivatives as novel antitubulin agents
    Qian, Yong
    Zhang, Hong-Jia
    Lv, Peng-Cheng
    Zhu, Hai-Liang
    BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (23) : 8218 - 8225
  • [7] SYNTHESIS OF SOME SULFONYL DERIVATIVES OF GUANIDINE
    KUTEPOV, DF
    KHOKHLOV, DN
    TUZHILKINA, VL
    ZHURNAL OBSHCHEI KHIMII, 1961, 31 (09): : 2825 - &
  • [8] A Fast Route for the Synthesis of Cyclic Guanidine Derivatives
    Kumar, Sudhir
    Kumar, Dinesh
    Renu
    ORIENTAL JOURNAL OF CHEMISTRY, 2011, 27 (01) : 191 - 196
  • [9] Streptomycin Hydrazone Derivatives: Synthesis and Molecular Recognition in Aqueous Solution
    Fuentes-Martinez, Juan P.
    Gutierrez-Rodriguez, Diana
    Rogel Garcia, Edgar
    Rivera-Marquez, Karla I.
    Medrano, Felipe
    Torres-Angeles, Oscar
    Castillo-Vargas, Evelin
    Duque Montano, Blanca E.
    Godoy-Alcantar, Carolina
    NATURAL PRODUCT COMMUNICATIONS, 2014, 9 (10) : 1449 - 1455
  • [10] Molecular Determinants of Hv1 Inhibition by Guanidine Derivatives
    Hong, Liang
    Kim, Iris
    Tombola, Francesco
    BIOPHYSICAL JOURNAL, 2013, 104 (02) : 207A - 207A