Orientational behaviors of silk fibroin hydrogels

被引:18
|
作者
Chen, Daqi [1 ]
Yin, Zhuping [1 ]
Wu, Feng [1 ]
Fu, Hua [1 ]
Kundu, Subhas C. [2 ,3 ]
Lu, Shenzhou [1 ]
机构
[1] Soochow Univ, Natl Engn Lab Modern Silk, Coll Text & Clothing Engn, Suzhou 215123, Peoples R China
[2] Indian Inst Technol, Dept Biotechnol, Kharagpur 721302, W Bengal, India
[3] Univ Minho, Res Grp 3Bs, Headquarters European Inst Excellence Tissue Engn, AvePk 4805-017, Barco Guimaraes, Portugal
基金
中国国家自然科学基金;
关键词
biomaterials; gels; mechanical properties; structure-property relationships; BIOMEDICAL APPLICATIONS; INTERFACIAL-TENSION; SURFACE-TENSION; TISSUE; BIOMATERIALS; GELATION; STATE; WATER;
D O I
10.1002/app.45050
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
In this study, a novel shear-induced silk fibroin (SF) hydrogel with three-dimensional (3D) anisotropic and oriented gel skeleton/network morphology is presented. Amphipathic anionic and nontoxic sodium surfactin is blended with the SF to decrease its gelation time during the mechanical shearing process. The fibroin/surfactin blended solutions undergo a facial shearing process to accomplish a sol-gel transition within 1 hour. The dynamic sol-gel transition kinetic analysis, gel skeleton/network morphology, and mechanical property measurements are determined in order to visualize the fibroin/surfactin sol-gel transition during the shearing process and its resulting hydrogel. The results demonstrate that there is significant beta-sheet assembly from random coil conformations in the fibroin/surfactin blended system during the facile shearing process. The SF beta-sheets further transform into a fibrous large-scale aggregation with orientational and parallel arrangements to the shearing direction. The shear-induced fibroin/surfactin hydrogel exhibits notable anisotropic and oriented 3D skeleton/network morphology and a significant mechanical compressive strength in proportion to the shearing stress, compared with the control fibroin/surfactin hydrogel undergoing no shearing process. Due to its oriented gel skeleton/network structure and significantly enhanced mechanical properties, the shear-induced fibroin/surfactin gel may be suitable as a biomaterial in 3D oriented tissue regeneration, including for nerves, the cultivation of bone cells, and the repair of defects in muscle and ligament tissues.(C) 2017 Wiley Periodicals, Inc.
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页数:9
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