Reaction of pyridazine and quinoline with silyl enol ethers in the presence of alkyl chloroformate

被引：0

作者：

Itoh, T ^{[1
]}

Miyazaki, M ^{[1
]}

Nagata, K ^{[1
]}

Ohsawa, A ^{[1
]}

机构：

[1] Showa Univ, Sch Pharmaceut Sci, Shinagawa Ku, Tokyo 142, Japan

来源：

HETEROCYCLES | 1997年 / 46卷

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyridazine was allowed to react with silyl enol ethers (or ketene silyl acetals) in the presence of ethyl chloroformate to give 4- and 6-substituted 1-ethoxycarbonyldihydropyridazines in good yields. The vicinal substituents of silyl enol ethers considerably affected the regioselectivity, and one of the two dihydroadducts was selectively obtained by the use of appropriate silyl enol ethers. Similar substituent effect was observed in the reaction of quinolines under the same conditions.

引用

页码：83 / 86

页数：4

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