Determination of clopidol residues in chicken tissues by high-performance liquid chromatography-mass spectrometry

被引:11
|
作者
Pang, GF [1 ]
Cao, YZ
Fan, CL
Zhang, JJ
Li, XM
Wang, C
机构
[1] Qinhuangdao Import & Export Commod Inspect Bur, Qinhuangdao 066002, PC, Peoples R China
[2] China Import & Export Commod Inspect Inst, Beijing 100025, PC, Peoples R China
关键词
meat; food analysis; clopidol;
D O I
10.1016/S0021-9673(00)00436-2
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A high-performance liquid chromatographic-mass spectrometric (HPLC-MS) method has been developed for determination of clopidol residues in chicken tissues. Samples are extracted with acetonitrile. The extracts are cleaned up on an alumina column followed by an anion-exchange column. The clopidol is separated on a column (150 cmx4.6 mm) of Intertsil by using acetonitrile-water (20:80) as mobile phase. The clopidol was qualitatively identified by molecule mass and determined quantitatively by selected ion monitoring mode at 190 m/z. The recoveries with RSDs ranged from 91.6+/-10.1 to 97.3+/-5.7 at 0.010 to 10.0 mg/kg by spiking three matrices (chicken muscle, liver, and kidney). The limit of detection was 0.005 mg/kg, and the limit of quantification was 0.010 mg/kg. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:85 / 88
页数:4
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