Regulating voltage-gated ion channels with nanobodies

被引：1
|
作者：
Manning, Declan [1 ]
Santana, L. Fernando [1 ]
机构：
[1] Univ Calif Davis, Dept Physiol & Membrane Biol, One Shields Ave, Davis, CA 95616 USA
来源：
NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期
关键词：
CALCIUM-CHANNELS; SUBUNITS; PROTEINS;
D O I：
10.1038/s41467-022-35027-5
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this work, Morgenstern and colleagues describe an approach involving functionalized nanobodies which decrease the activity of voltage-gated Ca2+ channels associated with beta(1) subunits and promote their removal from the surface membrane of neurons and muscle.
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页数：2
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