Lung Volume Reduction Surgery and Lung Volume Reduction in Advanced Emphysema: Who and Why?

被引:11
|
作者
Criner, Gerard J. [1 ,2 ]
Mamary, A. James [1 ]
机构
[1] Temple Univ, Sch Med, Div Pulm & Crit Care Med, Philadelphia, PA 19140 USA
[2] Temple Univ, Sch Med, Temple Lung Ctr, Philadelphia, PA 19140 USA
关键词
Emphysema; COPD; lung volume reduction surgery; lung volume reduction; OBSTRUCTIVE PULMONARY-DISEASE; TREATMENT TRIAL; AIRWAY BYPASS; COLLATERAL VENTILATION; OPERATIVE TECHNIQUE; COST-EFFECTIVENESS; DIFFUSE EMPHYSEMA; RANDOMIZED-TRIAL; MEDICAL THERAPY; ELUTING STENTS;
D O I
10.1055/s-0030-1254075
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Emphysema is a disabling and progressive disease that is hallmarked by decreased exercise tolerance and impaired quality of life. Hyperinflation is the sentinel physiological characteristic of emphysema that has been shown to be responsible for exercise intolerance, dyspnea, impaired quality of life, and mortality. Surgical interventions that reduce lung volume have been the focus of multiple proposed interventions over the past century; however, evidence documenting their effectiveness has been lacking. Recently, lung volume reduction surgery (LVRS) has undergone rigorous study in the National Emphysema Treatment Trial (NETT) that documented its short and long-term effectiveness, associated morbidity and mortality, and essential characteristics that predict success or failure. Additional recent investigation has examined the use of less invasive techniques, predominantly bronchoscopic techniques that reduce lung volume without open thoracotomy. This article summarizes the major results of the NETT and briefly reviews some preliminary results of studies examining new techniques of bronchoscopic lung volume reduction.
引用
收藏
页码:348 / 364
页数:17
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