Anti-PKC activity of some 3-(dialkylamino)-1H-naphtho [2,1-b] pyran-1-ones

被引：0

作者：

Mazzei, M

Garzoglio, R

Sottofattori, E

Melloni, E

Michetti, M

机构：

[1] Dipartimento Sci Farmaceut, I-16132 Genoa, Italy

[2] Ist Chim Biol, I-16132 Genoa, Italy

来源：

FARMACO | 1997年 / 52卷 / 8-9期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Some 3-(dialkylamino)-1H-naphtho [2,1-b] pyran-1-ones were tested to evaluate their ability to inhibit Protein Kinase C (PKC) activation. The model consisted in the detection of the superoxide anion in activated neutrophils. Naphthopyrans carrying 3-(diethylamino), 3-(1-piperidinyl) and 3-[bis(2-methoxyethyl)amino] groups emerged as the most active ones. Introduction of alkoxy groups in position 8 and 9 and of bromo substituent in position 8 on the naphthalene moiety was associated with an increase in anti-PKC activity. No activity was found when an electron withdrawing group was placed in position 2 of the 3-(dialkylamino)-1H-naphtho [2,1-b] pyran-1-ones.

引用

页码：539 / 545

页数：7

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