Anti-PKC activity of some 3-(dialkylamino)-1H-naphtho [2,1-b] pyran-1-ones

被引：0
|
作者：
Mazzei, M
Garzoglio, R
Sottofattori, E
Melloni, E
Michetti, M
机构：
[1] Dipartimento Sci Farmaceut, I-16132 Genoa, Italy
[2] Ist Chim Biol, I-16132 Genoa, Italy
来源：
FARMACO | 1997年 / 52卷 / 8-9期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Some 3-(dialkylamino)-1H-naphtho [2,1-b] pyran-1-ones were tested to evaluate their ability to inhibit Protein Kinase C (PKC) activation. The model consisted in the detection of the superoxide anion in activated neutrophils. Naphthopyrans carrying 3-(diethylamino), 3-(1-piperidinyl) and 3-[bis(2-methoxyethyl)amino] groups emerged as the most active ones. Introduction of alkoxy groups in position 8 and 9 and of bromo substituent in position 8 on the naphthalene moiety was associated with an increase in anti-PKC activity. No activity was found when an electron withdrawing group was placed in position 2 of the 3-(dialkylamino)-1H-naphtho [2,1-b] pyran-1-ones.
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页码：539 / 545
页数：7
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