Palladium-Catalyzed Enantioselective Intermolecular Carboetherification of Dihydrofurans

被引：65
|
作者：
Borrajo-Calleja, Gustavo M. [1 ]
Bizet, Vincent [1 ]
Mazet, Clement [1 ]
机构：
[1] Univ Geneva, Dept Organ Chem, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 12期
基金：
瑞士国家科学基金会;
关键词：
PHOSPHINE OXIDE LIGANDS; HECK REACTION; STEREOSELECTIVE-SYNTHESIS; CARBOAMINATION REACTIONS; EFFICIENT SYNTHESIS; COUPLING REACTIONS; MONO-OXIDATION; CHIRAL LIGAND; ALKENES; TETRAHYDROFURANS;
D O I：
10.1021/jacs.6b02158
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel enantioselective Pd-catalyzed intermolecular carboetherification of dihydrofurans is reported. The in situ generation of chiral bis-phosphine mono-oxide ligands is crucial, and a general catalytic system has been identified based on this approach. It provides access to a variety of fused tetrahydrofurobenzofurans in consistently high yield and enantiomeric excess.
引用
收藏
页码：4014 / 4017
页数：4
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