Effects of tricyclic and tetracyclic antidepressants on the three subtypes of GABA transporter

被引：17
|
作者：
Nakashita, M [1 ]
Sasaki, K [1 ]
Sakai, N [1 ]
Saito, N [1 ]
机构：
[1] KOBE UNIV,BIOSIGNAL RES CTR,MOL PHARMACOL LAB,NADA KU,KOBE,HYOGO 657,JAPAN
来源：
NEUROSCIENCE RESEARCH | 1997年 / 29卷 / 01期
关键词：
depression; antidepressants; GABA transporter; subtype; serotonin transporter; uptake; COS-7; cell;
D O I：
10.1016/S0168-0102(97)00072-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We examined the effects of 11 antidepressants on the activities of three rat GABA transporters (GAT1, GAT2 and GAT3) expressed in COS-7 cells. Desipramine and maprotiline inhibited all subtypes of GABA transporter, while doxepin, mianserin, trimipramine, nortriptyline and amitriptyline inhibited certain types of GABA transporters. Amitriptyline inhibited the GAT1 and GAT3 at the reasonable dosage for clinical administration. These results suggest that the inhibition of GABA uptake might have some role in the prescribed antidepressive and sedative nature of this drug. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：87 / 91
页数：5
相关论文
共 50 条
  • [31] LIQUID-CHROMATOGRAPHIC DETERMINATION OF 8-TRICYCLIC AND TETRACYCLIC ANTIDEPRESSANTS AND THEIR MAJOR ACTIVE METABOLITES
    SUTFIN, TA
    DAMBROSIO, R
    JUSKO, WJ
    CLINICAL CHEMISTRY, 1984, 30 (03) : 471 - 474
  • [32] Combination therapy using moclobemide with tricyclic and tetracyclic antidepressants to treat therapy-resistant depression
    Konig, F
    Wolfersdorf, M
    PHARMACOPSYCHIATRY, 1997, 30 (03) : 93 - 96
  • [33] COMPARISON OF THE CHRONOTROPIC RESPONSES TO TRICYCLIC AND TETRACYCLIC ANTIDEPRESSANTS IN ISOLATED SINOATRIAL NODE PREPARATIONS FROM THE RABBIT
    KOTAKE, H
    HIRAI, S
    MATSUOKA, S
    KINUGAWA, T
    HASEGAWA, J
    MASHIBA, H
    ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, 1987, 289 (01): : 72 - 81
  • [34] EFFECTS OF TRICYCLIC ANTIDEPRESSANTS ON DRUG-METABOLISM
    POND, SM
    GRAHAM, GG
    BIRKETT, DJ
    WADE, DN
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1975, 18 (02) : 191 - 199
  • [35] Antinociceptive effects of tricyclic antidepressants and their noradrenergic metabolites
    Rojas-Corrales, MO
    Casas, J
    Moreno-Brea, MR
    Gibert-Rahola, J
    Micó, JA
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2003, 13 (05) : 355 - 363
  • [36] Effects of tricyclic antidepressants on intestinal pacemaker cells
    Kim, S. H.
    Hwang, G.
    Kim, H. R.
    Park, S. H.
    Jeon, J. Y.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2007, 17 : S374 - S375
  • [37] THE RELATIONSHIP OF ANTIOBSESSIONAL AND ANTIDEPRESSANT EFFECTS OF TRICYCLIC ANTIDEPRESSANTS
    MAVISSAKALIAN, M
    TURNER, SM
    MICHELSON, L
    JACOB, R
    PSYCHOPHARMACOLOGY BULLETIN, 1986, 22 (01) : 161 - 166
  • [38] EFFECTS OF VARIOUS TRICYCLIC ANTIDEPRESSANTS ON AMINE UPTAKE
    ISHIKAWA, K
    SHIBANOKI, S
    KUBO, T
    WATABE, S
    MATSUMOTO, A
    KOGURE, M
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 120 (01) : 63 - 68
  • [39] The effects of tricyclic antidepressants on breast cancer risk
    C R Sharpe
    J-P Collet
    E Belzile
    J A Hanley
    J-F Boivin
    British Journal of Cancer, 2002, 86 : 92 - 97
  • [40] REVIEW OF CARDIOVASCULAR EFFECTS AND TOXICITY OF TRICYCLIC ANTIDEPRESSANTS
    JEFFERSON, JW
    PSYCHOSOMATIC MEDICINE, 1975, 37 (02): : 160 - 179
12345