Synthesis, crystal structure, anti-colon cancer activity of a new heterocycles compound

被引：1
|
作者：
Liu, Zhi-Peng [1 ]
Yang, Hai-Lin [2 ]
Hou, Rui-Gang [1 ]
Li, En-Shan [3 ]
Liu, Xue-Jian [2 ]
机构：
[1] Shandong First Med Univ, Clin Med Coll, Tai An, Shandong, Peoples R China
[2] Peoples Hosp Linyi Econ & Technol Dev, Dept Oncol, Linyi, Shandong, Peoples R China
[3] Linyi Canc Hosp, Dept Surg, Linyi, Shandong, Peoples R China
来源：
MAIN GROUP CHEMISTRY | 2019年 / 18卷 / 04期
关键词：
Heterocycles; X-ray crystallography; anticancer activity;
D O I：
10.3233/MGC-190785
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The new heterocycles compound 3-morpholino-1-(4-(2-oxopiperidin-l-yOphenyl)-5,6-dihydropyridin-2(1H)-one (1), designed using 1-(4-nitrophenyl)piperidin-2-one (2) as start material, was successfully obtained via multiple synthesis route and finally characterized by IR, H-1 NMR, and single crystal X-ray crystallography. In addition, the in vitro anticancer activities of the newly synthesized complex 1 have been emulated against two human colon cancer cell lines SW620 and HCT116.
引用
收藏
页码：421 / 426
页数：6
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