A facile synthesis of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines

被引：3

作者：

Khan, Rasool ^{[1
]}

Arfan, Mohammad ^{[2
]}

Mahmood, Javeed ^{[2
]}

Anjum, Shazia ^{[3
]}

Choudhary, M. Iqbal ^{[4
]}

机构：

[1] Abdul Wali Khan Univ, Dept Chem, Mardan 23200, Nwfp, Pakistan

[2] Univ Peshawar, Inst Chem Sci, Peshawar 25120, Pakistan

[3] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 5C9, Canada

[4] Univ Karachi, Int Ctr Chem & Biol Sci, HEJRIC, Karachi 75270, Pakistan

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 08期

关键词：

3-Amino-2-phenyl-4(3H)-quinazolinone; Triethylorthoacetate; Unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines; AGENTS; QUINAZOLINONES; ACETAMIDINES;

D O I：

10.1016/j.cclet.2010.04.009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines was synthesized by reacting ethyl(1E)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)ethanimidoate (2) and suitable reactive aromatic amines. Structures' determination of the synthesized compounds was carried out using spectroscopic techniques including IR, (1)H NMR, and mass spectrometry. Structural effects on reactivity were also studied. (C) 2010 Rasool Khan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：905 / 910

页数：6

共 50 条

[31] Crystal Structures of N-[2-(4-oxo-4H-benzo[d] [1, 3]-oxazin-2-yl)benzamide and Propionamide and Their N-Containing Analog N-[2-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]propionamide
L. G. Kuz’mina
S. Yu. Salykin
S. V. Kulagin
K. E. Merkulov
B. M. Bolotin
Crystallography Reports, 2021, 66 : 413 - 419
[32] N-{4-[(2-phenyl-1H-indol-3-yl)diazenyl]phenyl}acetamide
Seferoglu, Zeynel
Hokelek, Tuncer
Sahin, Ertan
Ertan, Nermin
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O3492 - O3494
[33] Synthesis and Antimicrobial Activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl] pyridine-4-carboxamide
Thomas, Asha B.
Nanda, Rabindra K.
Kothapalli, Lata P.
Deshpande, Avinash D.
JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE, 2011, 55 (06): : 960 - 968
[34] Synthesis and antibacterial activity of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids N-(4-guanidylsulfonylphenyl)amides
Gein, V. L.
Bobrovskaya, O. V.
Kovtonogova, I. V.
Novikova, V. V.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2015, 85 (04) : 833 - 836
[35] Synthesis and antibacterial activity of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids N-(4-guanidylsulfonylphenyl)amides
V. L. Gein
O. V. Bobrovskaya
I. V. Kovtonogova
V. V. Novikova
Russian Journal of General Chemistry, 2015, 85 : 833 - 836
[36] Synthesis, crystal and molecular structures, and stereochemical nonrigidity of N-(chlorodimethylgermylmethyl)- and N-(bromodimethylgermylmethyl)-N-[(S)-1-phenylethyl]acetamides and N-(chlorodimethylgermylmethyl)-4-phenyl-2-pyrrolidone
Bylikin, SY
Pogozhikh, SA
Khrustalev, VN
Negrebetsky, VV
Shipov, AG
Ovchinnikov, YE
Baukov, YI
RUSSIAN CHEMICAL BULLETIN, 2000, 49 (01) : 140 - 147
[37] Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides
Andric, Deana B.
Dukic-Stefanovic, Sladjana
Krunic, Mihajlo J.
Jevtic, Ivana I.
Penjisevic, Jelena Z.
Sukalovic, Vladimir B.
Kostic-Rajacic, Sladana
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2024, 89 (03) : 291 - 303
[38] A FACILE SYNTHESIS OF N-(2-PYRIDYL AND 4-PYRIDYL)INDOLES
SEKI, K
OHKURA, K
TERASHIMA, M
KANAOKA, Y
HETEROCYCLES, 1994, 37 (02) : 993 - 996
[39] N-(3-chloro-4-methylphenyl)-N′-hydroxy-2-oxo-2-phenylacetamidine
Hökelek, T
Büyükgüngör, O
Tas, M
Bati, H
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2004, 60 : O406 - O408
[40] N-(3-Chloro-4-methoxyphenyl)-N′-hydroxy-2-oxo-2-phenylacetamidine
Soylu, S
Tas, M
Andaç, Ö
Bati, H
Çaliskan, N
Büyükgüngör, O
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2003, 59 : O1532 - O1534

← 1 2 3 4 5 →