MULTITYPE INFINITE-ALLELE BRANCHING PROCESSES IN CONTINUOUS TIME

被引:0
|
作者
McDonald, Thomas O. [1 ,2 ]
Kimmel, Marek [3 ,4 ]
机构
[1] Rice Univ, Houston, TX 77251 USA
[2] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Mailstop CLS 11054,450 Brookline Ave, Boston, MA 02115 USA
[3] Rice Univ, Dept Stat, MS-138,POB 1892, Houston, TX 77251 USA
[4] Silesian Tech Univ, Gliwice, Poland
基金
美国国家科学基金会;
关键词
Multitype branching process; infinite-allele model; EVOLUTION; VERSION;
D O I
10.1017/jpr.2017.17
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
We introduce extensions to an infinite-allele branching process that allows for multiple types to exist alongside labels. We consider a Markov branching process and general branching process under different assumptions, and show asymptotic results about the growth of the labels as well as the frequency spectrum. These results are motivated by two separate models. The Markov binary splitting results are motivated by a model of clonal evolution in cancer that considers the effect of both driver and passenger mutations on tumor growth. The general process has applications in viral reproduction and dynamics.
引用
收藏
页码:550 / 568
页数:19
相关论文
共 50 条