Identification of Potent and Selective Human Carbonic Anhydrase VII (hCA VII) Inhibitors

被引：22

作者：

Gitto, Rosaria ^{[1
]}

Agnello, Stefano ^{[1
]}

Ferro, Stefania ^{[1
]}

Vulio, Daniela ^{[2
]}

Supuran, Claudiu T. ^{[2
]}

Chimirri, Alba ^{[1
]}

机构：

[1] Univ Messina, Dipartimento Farmacochim, Fac Farm, I-98168 Messina, Italy

[2] Univ Florence, Lab Chim Bioinorgan, Florence, Italy

来源：

CHEMMEDCHEM | 2010年 / 5卷 / 06期

关键词：

carbonic anhydrases; drug design; enzymes; inhibitors; isoquinolines; BIOLOGICAL EVALUATION; BINDING FUNCTIONS; DNA CLONING; SULFONAMIDE; DESIGN; TARGET;

D O I：

10.1002/cmdc.201000044

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Figure Presented) Guarding the grey matter: This paper reports the discovery of sulfonamide derivatives as carbonic anhydrase inhibitors that selectively act against the hCA VII over the hCA II isoform. These compounds represent potentially useful lead structures for the further development of neuroprotective agents targeting the hCA VII isoform. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：823 / 826

页数：4

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