No evidence of fetal DNA persistence in maternal plasma after pregnancy

被引：46

作者：

Smid, M

Galbiati, S

Vassallo, A

Gambini, D

Ferrari, A

Viora, E

Pagliano, M

Restagno, G

Ferrari, M

Cremonesi, L ^{[1
]}

机构：

[1] IRCCS H San Raffaele, Unit Genomics Diagnost Human Pathol, I-20132 Milan, Italy

[2] H San Raffaele, Dept Obstet & Gynecol, Milan, Italy

[3] Osped S Anna, Ctr Ecografia & Diagnosi Prenatale, Turin, Italy

[4] Univ Turin, Cattera A, I-10124 Turin, Italy

[5] AOOIRM S Anna, Dipartimento Patol Clin, Turin, Italy

[6] H San Raffaele, Diagnost & Ric S Raffaele SpA, Milan, Italy

来源：

HUMAN GENETICS | 2003年 / 112卷 / 5-6期

关键词：

D O I：

10.1007/s00439-003-0919-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Short- and long-term persistence of fetal DNA in maternal plasma has been investigated. Short-term persistence at very low concentration was detected in 47 out of 105 women within two days after delivery. Twelve out of 13 samples re-tested within three days scored negative. No long-term persistence was detected in 172 women who had previous sons or abortions. Molecular micro-chimerism due to circulating fetal DNA persisting from previous pregnancies should not hamper non-invasive plasma-based prenatal testing.

引用

页码：617 / 618

页数：2

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