Copper-Catalyzed Synthesis of β- and δ-Carbolines by Double N-Arylation of Primary Amines

被引：7

作者：

Ban Van Phuc ^{[1
]}

Ha Nam Do ^{[2
]}

Nguyen Minh Quan ^{[3
]}

Nguyen Ngoc Tuan ^{[1
]}

Nguyen Quang An ^{[1
]}

Nguyen Van Tuyen ^{[1
,3
]}

Hoang Le Tuan Anh ^{[4
]}

Tran Quang Hung ^{[1
,3
]}

Tuan Thanh Dang ^{[2
]}

Langer, Peter ^{[5
,6
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Chem, 18-Hoang Quoc Viet, Hanoi, Vietnam

[2] Vietnam Natl Univ VNU, Hanoi Univ Sci, Fac Chem, 19 Le Thanh Tong, Hanoi, Vietnam

[3] Vietnam Acad Sci & Technol, Grad Univ Sci & Technol, 18 Hoang Quoc Viet, Hanoi, Vietnam

[4] Vietnam Acad Sci & Technol, Ctr Res & Technol Transfer, 18 Hoang Quoc Viet, Hanoi, Vietnam

[5] Univ Rostock, Inst Chem, Albert Einstein Str 3a, D-18059 Rostock, Germany

[6] Univ Rostock eV, Leibniz Inst Katalyse, Albert Einstein Str 3a, D-18059 Rostock, Germany

来源：

SYNLETT | 2021年 / 32卷 / 10期

关键词：

catalysis; heterocycles; cross-coupling; cyclizations; copper; BIOLOGICAL EVALUATION; GAMMA-CARBOLINES; HOST MATERIALS; IN-VITRO; DERIVATIVES; CYCLIZATION; ANALOGS; ALPHA; CRYPTOLEPINE; ALKALOIDS;

D O I：

10.1055/s-0040-1720461

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two efficient and practical approaches are reported for the synthesis of beta- and delta-carbolines from 3,4-dibromopyridine. The synthesis is based on site-selective Cu-catalyzed double C-N coupling reactions and subsequent annulations by twofold Pd-catalyzed C-N coupling with amines.

引用

页码：1004 / 1008

页数：5

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