A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia

被引：72

作者：

Skeith, Leslie ^{[1
,2
,3
]}

Carrier, Marc ^{[1
,2
,3
,4
]}

Kaaja, Risto ^{[5
,6
]}

Martinelli, Ida ^{[7
]}

Petroff, David ^{[8
]}

Schleussner, Ekkehard ^{[9
]}

Laskin, Carl A. ^{[10
,11
,12
]}

Rodger, Marc A. ^{[1
,2
,3
,4
,13
]}

机构：

[1] Univ Ottawa, Div Hematol, Ottawa Blood Dis Ctr, Ottawa, ON, Canada

[2] Univ Ottawa, Dept Med, Ottawa, ON, Canada

[3] Ottawa Gen Hosp, Ottawa, ON K1H 8L6, Canada

[4] Ottawa Gen Hosp, Res Inst, Clin Epidemiol Program, Ottawa, ON K1H 8L6, Canada

[5] Univ Turku, Dept Med, Turku, Finland

[6] Turku Univ Hosp, FIN-20520 Turku, Finland

[7] Osped Maggiore Policlin, Fdn Ist Ricovero & Cura Carattere Sci Ca Granda, A Bianchi Bonomi Hemophilia & Thrombosis Ctr, Milan, Italy

[8] Univ Leipzig, Clin Trial Ctr, D-04109 Leipzig, Germany

[9] Friedrich Schiller Univ Hosp, Dept Obstet & Gynecol, Jena, Germany

[10] LifeQuest Ctr Reprod Med, Toronto, ON, Canada

[11] Univ Toronto, Dept Med, Toronto, ON, Canada

[12] Univ Toronto, Dept Obstet & Gynecol, Toronto, ON, Canada

[13] Univ Ottawa, Dept Obstet & Gynecol, Ottawa, ON, Canada

来源：

BLOOD | 2016年 / 127卷 / 13期

关键词：

LOW-DOSE ASPIRIN; RECURRENT MISCARRIAGE; CONSENSUS STATEMENT; FETAL LOSS; MULTICENTER; ASSOCIATION; DEFINITION; ANTIBODIES; DISEASE; TRIAL;

D O I：

10.1182/blood-2015-12-626739

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We performed a meta-analysis of randomized controlled trials comparing low-molecular-weight heparin (LMWH) vs no LMWH in women with inherited thrombophilia and prior late (>= 10 weeks) or recurrent early (<10 weeks) pregnancy loss. Eight trials and 483 patients met our inclusion criteria. There was no significant difference in livebirth rates with the use of LMWH compared with no LMWH (relative risk, 0.81; 95% confidence interval, 0.55-1.19; P = .28), suggesting no benefit of LMWH in preventing recurrent pregnancy loss in women with inherited thrombophilia.

引用

页码：1650 / 1655

页数：6

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