Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort

被引：5

作者：

Bilous, Nadiia ^{[1
]}

Bomben, Riccardo ^{[2
]}

Dal Bo, Michele ^{[2
]}

Capello, Daniela ^{[3
,13
]}

Forconi, Francesco ^{[4
]}

Laurenti, Luca ^{[5
]}

Bertoni, Francesco ^{[6
,7
]}

Efremov, Dimitar G. ^{[8
]}

Marasca, Roberto ^{[9
]}

Del Poeta, Giovanni ^{[10
,11
]}

Martina, Zoya ^{[1
]}

Kryachouk, Iryna ^{[12
]}

Dyagil, Iryna ^{[1
]}

Gaidano, Gianluca ^{[3
,13
]}

Chumak, Anatoliy ^{[1
]}

Gattei, Valter ^{[2
]}

Abramenko, Iryna ^{[1
]}

机构：

[1] Ukraine Acad Med Sci, Res Ctr Radiat Med, Kiev, Ukraine

[2] IRCCS, Ctr Riferimento Oncol, Clin & Expt Oncohematol Unit, Aviano, Italy

[3] Amedeo Avogadro Univ Eastern Piedmont, Dept Clin & Expt Med, Div Hematol, Novara, Italy

[4] Univ Siena, Dept Clin Med & Immunol Sci, Div Hematol & Transplant, I-53100 Siena, Italy

[5] Univ Cattolica Sacro Cuore, Inst Hematol, Rome, Italy

[6] Oncol Inst So Switzerland IOSI, Expt Oncol Lab, Bellinzona, Switzerland

[7] Oncol Inst So Switzerland IOSI, Lymphoma Unit, Bellinzona, Switzerland

[8] CNR, ICGEB Outstn Monterotondo, Rome, Italy

[9] Univ Modena & Reggio Emilia, Dept Hematol & Oncol, Div Hematol, Modena, Italy

[10] Univ Roma Tor Vergata, Rome, Italy

[11] S Eugenio Hosp, Div Hematol, Rome, Italy

[12] Natl Canc Inst, Kiev, Ukraine

[13] Amedeo Avogadro Univ Eastern Piedmont, BRMA, Novara, Italy

来源：

LEUKEMIA & LYMPHOMA | 2010年 / 51卷 / 05期

关键词：

SOMATIC HYPERMUTATION; PATHOGENETIC IMPLICATIONS; IMMUNOGLOBULIN HEAVY; ITALIAN MULTICENTER; ANTIGEN SELECTION; GENE-MUTATIONS; USAGE; DIAGNOSIS; REPERTOIRE; GUIDELINES;

D O I：

10.3109/10428191003646002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A fraction of chronic lymphocytic leukemia (CLL) carries highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain complementarity-determining region-3 (HCDR3), often associated with a restricted selection of IG(K/L)V light chains. We analyzed the features of CLL expressing homologous HCDR3 in a cohort of 264 Ukrainian patients by merging them with a recently published reference series of 1426 cases. This approach allowed us to identify 96/264 (36%) cases as expressing homologous HCDR3, subdivided into 47 subsets. Among these, 27 apparently novel subsets were identified, although most of them were composed of two sequences per subset ('potential subsets'). CLL cases belonging to several stereotyped subsets showed HCDR3 homologies with various autoreactive clones. Our analysis identified molecular and clinical features of a Ukrainian cohort of patients with CLL.</.

引用

页码：822 / 838

页数：17

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