Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort

被引：5

作者：

Bilous, Nadiia ^{[1
]}

Bomben, Riccardo ^{[2
]}

Dal Bo, Michele ^{[2
]}

Capello, Daniela ^{[3
,13
]}

Forconi, Francesco ^{[4
]}

Laurenti, Luca ^{[5
]}

Bertoni, Francesco ^{[6
,7
]}

Efremov, Dimitar G. ^{[8
]}

Marasca, Roberto ^{[9
]}

Del Poeta, Giovanni ^{[10
,11
]}

Martina, Zoya ^{[1
]}

Kryachouk, Iryna ^{[12
]}

Dyagil, Iryna ^{[1
]}

Gaidano, Gianluca ^{[3
,13
]}

Chumak, Anatoliy ^{[1
]}

Gattei, Valter ^{[2
]}

Abramenko, Iryna ^{[1
]}

机构：

[1] Ukraine Acad Med Sci, Res Ctr Radiat Med, Kiev, Ukraine

[2] IRCCS, Ctr Riferimento Oncol, Clin & Expt Oncohematol Unit, Aviano, Italy

[3] Amedeo Avogadro Univ Eastern Piedmont, Dept Clin & Expt Med, Div Hematol, Novara, Italy

[4] Univ Siena, Dept Clin Med & Immunol Sci, Div Hematol & Transplant, I-53100 Siena, Italy

[5] Univ Cattolica Sacro Cuore, Inst Hematol, Rome, Italy

[6] Oncol Inst So Switzerland IOSI, Expt Oncol Lab, Bellinzona, Switzerland

[7] Oncol Inst So Switzerland IOSI, Lymphoma Unit, Bellinzona, Switzerland

[8] CNR, ICGEB Outstn Monterotondo, Rome, Italy

[9] Univ Modena & Reggio Emilia, Dept Hematol & Oncol, Div Hematol, Modena, Italy

[10] Univ Roma Tor Vergata, Rome, Italy

[11] S Eugenio Hosp, Div Hematol, Rome, Italy

[12] Natl Canc Inst, Kiev, Ukraine

[13] Amedeo Avogadro Univ Eastern Piedmont, BRMA, Novara, Italy

来源：

LEUKEMIA & LYMPHOMA | 2010年 / 51卷 / 05期

关键词：

SOMATIC HYPERMUTATION; PATHOGENETIC IMPLICATIONS; IMMUNOGLOBULIN HEAVY; ITALIAN MULTICENTER; ANTIGEN SELECTION; GENE-MUTATIONS; USAGE; DIAGNOSIS; REPERTOIRE; GUIDELINES;

D O I：

10.3109/10428191003646002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A fraction of chronic lymphocytic leukemia (CLL) carries highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain complementarity-determining region-3 (HCDR3), often associated with a restricted selection of IG(K/L)V light chains. We analyzed the features of CLL expressing homologous HCDR3 in a cohort of 264 Ukrainian patients by merging them with a recently published reference series of 1426 cases. This approach allowed us to identify 96/264 (36%) cases as expressing homologous HCDR3, subdivided into 47 subsets. Among these, 27 apparently novel subsets were identified, although most of them were composed of two sequences per subset ('potential subsets'). CLL cases belonging to several stereotyped subsets showed HCDR3 homologies with various autoreactive clones. Our analysis identified molecular and clinical features of a Ukrainian cohort of patients with CLL.</.

引用

页码：822 / 838

页数：17

共 50 条

[1] Relevance of Stereotyped B-Cell Receptors in the Context of the Molecular, Cytogenetic and Clinical Features of Chronic Lymphocytic Leukemia
Maura, Francesco
Cutrona, Giovanna
Fabris, Sonia
Colombo, Monica
Tuana, Giacomo
Agnelli, Luca
Matis, Serena
Lionetti, Marta
Gentile, Massimo
Recchia, Anna Grazia
Di Raimondo, Francesco
Musolino, Caterina
Ilariucci, Fiorella
Di Renzo, Nicola
Pesce, Emanuela
Molica, Stefano
Federico, Massimo
Cortelezzi, Agostino
Morabito, Fortunato
Ferrarini, Manlio
Neri, Antonino
PLOS ONE, 2011, 6 (08):
[2] MOLECULAR AND CLINICAL FEATURES OF B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA WITH OR WITHOUT STEREOTYPED B-CELL RECEPTORS: AN ITALIAN MULTICENTRIC EXPERIENCE
Bomben, R.
Dal Bo, M.
Capello, D.
Forconi, F.
Zucchetto, A.
Maffei, R.
Laurenti, L.
Bertoni, F.
Bulian, P.
Rossi, D.
Del Principe, M., I
Ilariucci, F.
Sozzi, E.
Spina, V
Zucca, E.
Degan, M.
Lauria, F.
Del Poeta, G.
Efremov, D. G.
Marasca, R.
Gaidano, G.
Gattei, V
HAEMATOLOGICA, 2008, 93 : S91 - S91
[3] Stereotyped B-cell receptors in chronic lymphocytic leukemia
Agathangelidis, Andreas
Vardi, Anna
Baliakas, Panagiotis
Stamatopoulos, Kostas
LEUKEMIA & LYMPHOMA, 2014, 55 (10) : 2252 - 2261
[4] Biological and clinical significance of stereotyped B-cell receptors in chronic lymphocytic leukemia
Rossi, Davide
Gaidano, Gianluca
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 (12): : 1992 - 1995
[5] Molecular and clinical features of B cell chronic lymphocytic leukemia(CLL) carrying stereotyped B-cell receptors: An Italian experience.
Bomben, Riccardo
Dal-Bo, Michele
Capello, Danicla
Forconi, Francesco
Zucchetto, Antonella
Maffei, Rossana
Laurenti, Luca
Bertoni, Francesco
Bulian, Pietro
Rossi, Davide
Del-Principe, Maria Ilaria
Ilariucci, Fiorella
Sozzi, Elisa
Zucca, Emanuele
Degan, Massimo
Lauria, Francesco
Del-Poeta, Giovanni
Efremov, Dimitar G.
Marasca, Roberto
Gaidano, Gianluca
Gattei, Valter
BLOOD, 2007, 110 (11) : 909A - 909A
[6] The Significance of Stereotyped B-Cell Receptors in Chronic Lymphocytic Leukemia
Darzentas, Nikos
Stamatopoulos, Kostas
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2013, 27 (02) : 237 - +
[7] Stereotyped B-cell receptors in the context of a diverse Brazilian series of chronic lymphocytic leukemia
Torres, Davi Coe
Emmel, Vanessa
Tascheri, Veronica
Campos, Mercia Mendes
Bigni, Ricardo de Sa
Sabino, Adriano de Paula
Yamamoto, Mihoko
Campregher, Paulo Vidal
Cartaxo Muniz, Maria Tereza
Abdelhay, Eliana
Hassan, Rocio
BLOOD CELLS MOLECULES AND DISEASES, 2021, 86
[8] Immune Thrombocytopenia in Patients with Chronic Lymphocytic Leukemia Is Associated with Stereotyped B-cell Receptors
Visco, Carlo
Maura, Francesco
Tuana, Giacomo
Agnelli, Luca
Lionetti, Marta
Fabris, Sonia
Novella, Elisabetta
Giaretta, Ilaria
Reda, Gianluigi
Barcellini, Wilma
Baldini, Luca
Neri, Antonino
Rodeghiero, Francesco
Cortelezzi, Agostino
CLINICAL CANCER RESEARCH, 2012, 18 (07) : 1870 - 1878
[9] Immune Thrombocytopenia in Patients with Chronic Lymphocytic Leukemia Is Associated with Stereotyped B-Cell Receptors
Maura, Francesco
Visco, Carlo
Novella, Elisabetta
Giaretta, Ilaria
Tuana, Giacomo
Agnelli, Luca
Lionetti, Marta
Fabris, Sonia
Guidotti, Francesca
Reda, Gianluigi
Gritti, Giuseppe
Barcellini, Wilma
Baldini, Luca
Neri, Antonino
Rodeghiero, Francesco
Cortelezzi, Agostino
BLOOD, 2011, 118 (21) : 1228 - 1228
[10] Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies
Agathangelidis, Andreas
Darzentas, Nikos
Hadzidimitriou, Anastasia
Brochet, Xavier
Murray, Fiona
Yan, Xiao-Jie
Davis, Zadie
van Gastel-Mol, Ellen J.
Tresoldi, Cristina
Chu, Charles C.
Cahill, Nicola
Giudicelli, Veronique
Tichy, Boris
Pedersen, Lone Bredo
Foroni, Letizia
Bonello, Lisa
Janus, Agnieszka
Smedby, Karin
Anagnostopoulos, Achilles
Merle-Beral, Helene
Laoutaris, Nikolaos
Juliusson, Gunnar
di Celle, Paola Francia
Pospisilova, Sarka
Jurlander, Jesper
Geisler, Christian
Tsaftaris, Athanasios
Lefranc, Marie-Paule
Langerak, Anton W.
Oscier, David Graham
Chiorazzi, Nicholas
Belessi, Chrysoula
Davi, Frederic
Rosenquist, Richard
Ghia, Paolo
Stamatopoulos, Kostas
BLOOD, 2012, 119 (19) : 4467 - 4475

← 1 2 3 4 5 →