Regulation of the biosynthesis of large dense-core vesicles in chromaffin cells and neurons

被引：24
|
作者：
Winkler, H [1 ]
Fischer-Colbrie, R [1 ]
机构：
[1] Univ Innsbruck, Dept Pharmacol, A-6020 Innsbruck, Austria
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 1998年 / 18卷 / 02期
关键词：
neuropeptide; chromogranins; secretogranin; VGF; prohormone convertases; cytochrome b-561;
D O I：
10.1023/A:1022516919932
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
1. The proteins of large dense-core vesicles (LDV) in neuroendocrine tissues are well characterized. Secretory components comprise chromogranins and neuropeptides. Intrinsic membrane proteins include cytochrome b-561, transporters, SV2, synaptotagmin, and synaptobrevin. 2. The effects of stimulation and of second messengers on the biosynthesis of LDV have been studied in detail. 3. Regulation of biosynthesis is complex. The cell can adapt to prolonged stimulation either by producing vesicles of normal size filled with a higher quantum of secretory peptides or by forming larger vesicles. In addition, some components, e.g., enzymes, can be upregulated specifically.
引用
收藏
页码：193 / 209
页数：17
相关论文
共 50 条
  • [21] LARGE DENSE-CORE VESICLES IN RAT ADRENAL AFTER RESERPINE - LEVELS OF MESSENGER-RNAS OF SOLUBLE AND MEMBRANE-BOUND CONSTITUENTS IN CHROMAFFIN AND GANGLION-CELLS INDICATE A BIOSYNTHESIS OF VESICLES WITH HIGHER SECRETORY QUANTA
    LASLOP, A
    MAHATA, SK
    WOLKERSDORFER, M
    MAHATA, M
    SRIVASTAVA, M
    SEIDAH, NG
    FISCHERCOLBRIE, R
    WINKLER, H
    JOURNAL OF NEUROCHEMISTRY, 1994, 62 (06) : 2448 - 2456
  • [22] Deciphering Dead-End Docking of Large Dense Core Vesicles in Bovine Chromaffin Cells
    Hugo, Sandra
    Dembla, Ekta
    Halimani, Mahantappa
    Matti, Ulf
    Rettig, Jens
    Becherer, Ute
    JOURNAL OF NEUROSCIENCE, 2013, 33 (43): : 17123 - 17137
  • [23] CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles
    Liu, Yuanyuan
    Schirra, Claudia
    Stevens, David R.
    Matti, Ulf
    Speidel, Dina
    Hof, Detlef
    Bruns, Dieter
    Brose, Nils
    Rettig, Jens
    JOURNAL OF NEUROSCIENCE, 2008, 28 (21): : 5594 - 5601
  • [24] SYNAPTOTAGMIN - A MEMBRANE CONSTITUENT OF NEUROPEPTIDE-CONTAINING LARGE DENSE-CORE VESICLES
    WALCHSOLIMENA, C
    TAKEI, K
    MAREK, KL
    MIDYETT, K
    SUDHOF, TC
    DECAMILLI, P
    JAHN, R
    JOURNAL OF NEUROSCIENCE, 1993, 13 (09): : 3895 - 3903
  • [25] Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells
    Dandoy-Dron, F
    Griffond, B
    Mishal, Z
    Tovey, MG
    Dron, M
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 18 (09) : 2449 - 2459
  • [26] MEMBRANE-ANTIGENS OF ENDOCRINE, LARGE DENSE-CORE AND SMALL SYNAPTIC VESICLES
    WINKLER, H
    SCHMIDLE, T
    FISCHERCOLBRIE, R
    KAPELARI, S
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1991, 19 (01) : 79 - 83
  • [27] CAPS1 regulates catecholamine loading of large dense-core vesicles
    Speidel, D
    Bruederle, CE
    Enk, C
    Voets, T
    Varoqueaux, F
    Reim, K
    Becherer, U
    Fornal, F
    Ruggieri, S
    Holighaus, Y
    Weihe, E
    Bruns, D
    Brose, N
    Rettig, J
    NEURON, 2005, 46 (01) : 75 - 88
  • [28] Costorage of BDNF and neuropeptides within individual dense-core vesicles in central and peripheral neurons
    Salio, C.
    Averill, S.
    Priestley, J. V.
    Merighi, A.
    DEVELOPMENTAL NEUROBIOLOGY, 2007, 67 (03) : 326 - 338
  • [29] The role of snapin in neurosecretion:: Snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells
    Tian, JH
    Wu, ZX
    Unzicker, M
    Lu, L
    Cai, Q
    Li, CL
    Schirra, C
    Matti, U
    Stevens, D
    Deng, CX
    Rettig, J
    Sheng, ZH
    JOURNAL OF NEUROSCIENCE, 2005, 25 (45): : 10546 - 10555
  • [30] Proneuropeptide Y processing in large dense-core vesicles: Manipulation of prohormone convertase expression in sympathetic neurons using adenoviruses
    Paquet, L
    Massie, B
    Mains, RE
    JOURNAL OF NEUROSCIENCE, 1996, 16 (03): : 964 - 973
12345