Gut Microbiome in Non-Alcoholic Fatty Liver Disease: From Mechanisms to Therapeutic Role

被引：18

作者：

Gupta, Haripriya ^{[1
]}

Min, Byeong-Hyun ^{[1
]}

Ganesan, Raja ^{[1
]}

Gebru, Yoseph Asmelash ^{[1
]}

Sharma, Satya Priya ^{[1
]}

Park, Eunju ^{[1
]}

Won, Sung-Min ^{[1
]}

Jeong, Jin-Ju ^{[1
]}

Lee, Su-Been ^{[1
]}

Cha, Min-Gi ^{[1
]}

Kwon, Goo-Hyun ^{[1
]}

Jeong, Min-Kyo ^{[1
]}

Hyun, Ji-Ye ^{[1
]}

Eom, Jung-A ^{[1
]}

Park, Hee-Jin ^{[1
]}

Yoon, Sang-Jun ^{[1
]}

Choi, Mi-Ran ^{[1
]}

Kim, Dong-Joon ^{[1
]}

Suk, Ki-Tae ^{[1
]}

机构：

[1] Hallym Univ, Coll Med, Inst Liver & Digest Dis, Chunchon 24252, South Korea

来源：

BIOMEDICINES | 2022年 / 10卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

microbiota; NAFLD; microbial functions; microbiota-based approach; DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPATIC STEATOSIS; TRYPTOPHAN-METABOLITES; ADIPOSE-TISSUE; SYNBIOTIC SUPPLEMENTATION; INTESTINAL MICROBIOTA; HIGH-CARBOHYDRATE; BARRIER FUNCTION;

D O I：

10.3390/biomedicines10030550

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD) is considered to be a significant health threat globally, and has attracted growing concern in the research field of liver diseases. NAFLD comprises multifarious fatty degenerative disorders in the liver, including simple steatosis, steatohepatitis and fibrosis. The fundamental pathophysiology of NAFLD is complex and multifactor-driven. In addition to viruses, metabolic syndrome and alcohol, evidence has recently indicated that the microbiome is related to the development and progression of NAFLD. In this review, we summarize the possible microbiota-based therapeutic approaches and highlight the importance of establishing the diagnosis of NAFLD through the different spectra of the disease via the gut-liver axis.

引用

页数：24

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