Paradoxical role of SOX2 in gastric cancer

被引：2
|
作者：
Carrasco-Garcia, Estefania [2 ]
Santos, Juliana C. [1 ]
Garcia, Idoia [2 ,3 ]
Brianti, Mitsue [1 ]
Garcia-Puga, Mikel [2 ]
Pedrazzoli, Jose, Jr. [1 ]
Matheu, Ander [2 ,3 ]
Ribeiro, Marcelo L. [1 ]
机构：
[1] Univ San Francisco, Unidade Integrada Farmacol & Gastroenterol, Braganca Paulista, SP, Brazil
[2] Biodonostia Hlth Res Inst, Neurooncol Grp, Paseo Dr Beguiristain S-N, San Sebastian 20014, Spain
[3] Ikerbasque, Basque Fdn, E-48011 Bilbao, Spain
来源：
AMERICAN JOURNAL OF CANCER RESEARCH | 2016年 / 6卷 / 04期
基金：
巴西圣保罗研究基金会;
关键词：
SOX2; gastric cancer; H; pylori; stem cells; BOX PROTEIN SOX2; HELICOBACTER-PYLORI; STEM-CELLS; INTESTINAL METAPLASIA; TRANSCRIPTION FACTORS; INITIATING CELLS; PROGENITOR CELLS; EXPRESSION; MOUSE; GENE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sox2 is a critical regulator of embryogenesis and necessary for cellular reprogramming. It also plays an important role in tissue homeostasis and regeneration, maintaining the population of undifferentiated adult stem cells. Like various developmental and stem cell genes, SOX2 is aberrantly expressed and amplified in several human cancers. Moreover, functional studies have shown that it regulates many biological processes including cell proliferation, apoptosis, self-renewal and invasion. While it is oncogenic in most cancers, SOX2 activity is controversial in gastric cancer, where it might behave as a tumor suppressor in some situations. In this review, we discuss its role in cancer biology, with particular attention to what is known about the involvement of SOX2 in gastric cancer biology.
引用
收藏
页码：701 / 713
页数：13
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