Recurrence pattern analysis after [68Ga]-DOTATATE-PET/CT-planned radiotherapy of high-grade meningiomas

被引:19
|
作者
Zollner, Barbara [1 ]
Ganswindt, Ute [1 ]
Maihoefer, Cornelius [1 ]
Corradini, Stefanie [1 ]
Albert, Nathalie Lisa [2 ]
Schichor, Christian [3 ]
Belka, Claus [1 ,4 ,5 ]
Niyazi, Maximilian [1 ,4 ,5 ]
机构
[1] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Radiat Oncol, Marchioninistr 15, D-81377 Munich, Germany
[2] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Nucl Med, Marchioninistr 15, D-81377 Munich, Germany
[3] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Neurosurg, Marchioninistr 15, D-81377 Munich, Germany
[4] German Canc Consortium DKTK, Partner Site Munich, Munich, Germany
[5] German Canc Res Ctr, Heidelberg, Germany
来源
RADIATION ONCOLOGY | 2018年 / 13卷
关键词
Atypical and anaplastic meningioma; Radiotherapy; Recurrence pattern; Safety margin; IMRT; STEREOTACTIC RADIOTHERAPY; ANAPLASTIC MENINGIOMAS; ADJUVANT RADIOTHERAPY; PROTON THERAPY; DIAGNOSIS; SURVIVAL; FAILURE; CLASSIFICATION; IRRADIATION; TUMORS;
D O I
10.1186/s13014-018-1056-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The aim of the present study was to evaluate the influence of the applied safety margins of modern intensity-modulated radiotherapy (IMRT) in patients with high-grade meningiomas on local control and recurrence patterns. Methods: Twenty patients with a neuropathological diagnosis of a high-grade meningioma (WHO degrees II or degrees III) treated with adjuvant or definitive radiotherapy between 2010 and 2015 were included in the present retrospective analysis. All patients were planned PET-based. Recurrence patterns were assessed by means of MRI and/or DOTATATE-PET/computertomography (CT). Results: The median follow-up was 31.0 months [95% confidence interval (CI): 20.1-42.0] and the progressionfree survival (PFS) after 24 months was 87.5%. Overall, four patients had a local recurrence of their meningioma. Of these, three were located in field according to the prior radiotherapy treatment region, while only one patient had a distant relapse. There were no independent factors influencing progression-free or overall survival (OS). Conclusion: After radiotherapy (RT), patients with atypical or anaplastic meningiomas still have a defined risk of tumor recurrence. The aim of the present study was to examine mono-institutional data concerning target volume definition and recurrence patterns after radiotherapy of high-grade meningiomas as there are limited data available. Our data suggest that extended safety margins are necessary to achieve a favorable local control for high-grade meningiomas.
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页数:9
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