Nematicidal amide alkaloids from the seeds of Clausena lansium

被引：25

作者：

Fan, Yu-Jiao ^{[2
]}

Chen, Hui-Qin ^{[1
]}

Mei, Wen-Li ^{[1
]}

Kong, Fan-Dong ^{[1
]}

Li, Fei-Xiang ^{[1
]}

Chen, Peng-Wei ^{[1
]}

Cai, Cai-Hong ^{[1
]}

Huang, Mian-Jia ^{[2
]}

Dai, Hao-Fu ^{[1
]}

机构：

[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China

[2] Hainan Univ, Coll Hort & Landscape Architecture, Haikou 570228, Hainan, Peoples R China

来源：

FITOTERAPIA | 2018年 / 128卷

关键词：

Clausena lansium; Seeds; Amide alkaloids; Nematicidal activity; CARBAZOLE ALKALOIDS; LOUR; SKEELS; CONSTITUENTS; COUMARINS; LEAVES; PEELS;

D O I：

10.1016/j.fitote.2018.04.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new amide alkaloids (1-3, 5-6) were isolated from the seeds of Clausena lansium together with one new natural product (4) and four known analogues (7-10). The structures of the new amide alkaloids were elucidated based on a comprehensive spectroscopic data analysis including 1D and 2D NMR as well as HRESIMS, and by comparison with the literature. The bioactivity results showed that compound 8 expressed potent nematicidal activity against Panagrellus redivevus, with IC50 value of 0.12 mM, while compounds 3 and 5 presented moderate nematicidal activity with IC50 values of 2.75 and 3.93 mM, respectively (abamectin as the positive control with IC50 value of 1.05 mM).

引用

页码：20 / 25

页数：6

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