Alpha-crystallin

被引：551
|
作者：
Horwitz, J [1 ]
机构：
[1] Univ Calif Los Angeles, Sch Med, Jules Stein Eye Inst, Los Angeles, CA 90095 USA
来源：
EXPERIMENTAL EYE RESEARCH | 2003年 / 76卷 / 02期
关键词：
alpha-crystallin; small heat-shock proteins; chaperones; aggregation; cataract;
D O I：
10.1016/S0014-4835(02)00278-6
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Alpha A and alpha B-crystallins are a major protein component of the mammalian eye lens. Being a member of the small heat-shock protein family they possess chaperone-like function. The alpha-crystallins and especially alpha B is also found outside the lens having an extensive tissue distribution. Alpha B-crystallin is found to be over-expressed in many neurological diseases, and mutations in alpha A or B-crystallin can cause cataract and myopathy. This review deals with some of the unique properties of the alpha-crystallins emphasizing especially what we don't know about its function and structure. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：145 / 153
页数：9
相关论文
共 50 条
12345