The Role of Therapeutic Drug Monitoring in Pediatric HIV/AIDS

被引：4
|
作者：
Burger, David M. [1 ]
机构：
[1] Radboud Univ Nijmegen, Dept Clin Pharm, Med Ctr, NL-6525 ED Nijmegen, Netherlands
来源：
THERAPEUTIC DRUG MONITORING | 2010年 / 32卷 / 03期
关键词：
therapeutic drug monitoring; HIV; children; viral load; QUALITY-CONTROL PROGRAM; HIV-INFECTED CHILDREN; HIV-1-INFECTED CHILDREN; ANTIRETROVIRAL THERAPY; PLASMA-CONCENTRATIONS; PHARMACOKINETICS; GUIDELINES; NELFINAVIR; LAMIVUDINE; EFAVIRENZ;
D O I：
10.1097/FTD.0b013e3181ddf717
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
International guidelines do not recommend therapeutic drug monitoring (TDM) of HIV-infected children as a routine measurement as part of medical management. There are, however, several clinical scenarios in which TDM may be indicated. Underdosing may be one of the major risks, especially in younger children. No randomized controlled clinical trials have been conducted to assess the added value of TDM in HIV-infected children, making recommendations for TDM in children with HIV/AIDS merely based on expert opinion. There is a need for more descriptive studies on the usefulness of TDM in HIV-infected children to convince pediatricians worldwide to let more children benefit from TDM.
引用
收藏
页码：269 / 272
页数：4
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