Accumulating evidence indicates that systolic blood pressure and pulse pressure are strong predictors of cardiovascular disease after the age of 60. Arterial stiffness and myocardial fibrosis are strong correlates of isolated systolic hypertension and wide pulse pressure and maybe mediated by activation of the rennin angiotensin system. Aggressive treatment of systolic hypertension can provide substantial protection from cardiovascular complications and blockade of the renin-angiotensin-aldosterone system may provide additional benefits beyond blood pressure lowering.
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Univ Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, Canada
Tan, Nigel S.
Sarak, Bradley
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Univ Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, Canada
Sarak, Bradley
Fox, Keith A. A.
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Univ Edinburgh, Ctr Cardiovasc Sci, Edinburgh, Midlothian, ScotlandUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, Canada
Fox, Keith A. A.
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Brieger, David
Steg, Ph. Gabriel
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Univ Paris Diderot, Hop Bichat, AP HP, FACT,Dept Hosp Univ FIRE, Paris, France
INSERM, U1148, Paris, FranceUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, Canada
Steg, Ph. Gabriel
Gale, Chris P.
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Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, EnglandUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, Canada
Gale, Chris P.
Bhatt, Deepak L.
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Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USAUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, Canada
Bhatt, Deepak L.
Spencer, Frederick A.
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McMaster Univ, Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, Canada
Spencer, Frederick A.
Grondin, Francois R.
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Hotel Dieu Levis, Levis, PQ, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, Canada
Grondin, Francois R.
Goodman, Shaun G.
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Univ Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, Canada
Canadian Heart Res Ctr, Toronto, ON, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, Canada
Goodman, Shaun G.
Yan, Andrew T.
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Univ Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON, Canada
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Section of Hypertension and Clinical Pharmacology, University of Connecticut School of Medicine, Farmington, CT 06030-3940Section of Hypertension and Clinical Pharmacology, University of Connecticut School of Medicine, Farmington, CT 06030-3940
机构:
CHU St Etienne, Hop Bellevue, Serv Med Interne & Therapeut, Blvd Pasteur, F-42055 St Etienne, FranceCHU St Etienne, Hop Bellevue, Serv Med Interne & Therapeut, Blvd Pasteur, F-42055 St Etienne, France
Queneau, P
Asmar, R
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CHU St Etienne, Hop Bellevue, Serv Med Interne & Therapeut, Blvd Pasteur, F-42055 St Etienne, FranceCHU St Etienne, Hop Bellevue, Serv Med Interne & Therapeut, Blvd Pasteur, F-42055 St Etienne, France
Asmar, R
Safar, M
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CHU St Etienne, Hop Bellevue, Serv Med Interne & Therapeut, Blvd Pasteur, F-42055 St Etienne, FranceCHU St Etienne, Hop Bellevue, Serv Med Interne & Therapeut, Blvd Pasteur, F-42055 St Etienne, France