Practical asymmetric synthesis of 1,2-diamines in the 3-aminoazepane series

被引：23
|
作者：
Cutri, S
Bonin, M
Micouin, L
Husson, HP
Chiaroni, A
机构：
[1] Univ Paris 05, Fac Sci Pharmaceut & Biol, F-75270 Paris 06, France
[2] Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 07期
关键词：
D O I：
10.1021/jo026711s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and versatile method for the enantio- and diastereoselective synthesis of mono- or disubstituted 3-aminoazepanes is described. The key step involves a highly regio- and diastereoselective tandem ring-enlargement/alkylation or reduction process. This novel synthetic route provides enantiomerically pure constrained diamines interesting as scaffolds for medicinal chemistry.
引用
收藏
页码：2645 / 2651
页数：7
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