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Performance of Lung Ultrasound for Monitoring Interstitial Lung Disease
被引:13
|作者:
Pitsidianakis, Georgios
[1
]
Vassalou, Evangelia E.
[1
,2
,3
]
Vasarmidi, Eirini
[1
]
Bolaki, Maria
[4
]
Klontzas, Michail E.
[2
]
Xirouchaki, Nektaria
[4
]
Georgopoulos, Dimitrios
[4
]
Karantanas, Apostolos H.
[2
,5
]
Tzanakis, Nikolaos
[1
]
Antoniou, Katerina M.
[1
]
机构:
[1] Heraklion Univ Hosp, Dept Resp Med, Iraklion, Greece
[2] Heraklion Univ Hosp, Dept Med Imaging, Iraklion, Greece
[3] Sitia Gen Hosp, Dept Med Imaging, Sitia, Greece
[4] Heraklion Univ Hosp, Dept Intens Care Med, Iraklion, Greece
[5] Univ Crete, Med Sch, Dept Radiol, Iraklion, Greece
关键词:
disease monitoring;
high-resolution tomography;
X-ray computed;
HRCT;
interstitial lung disease;
ultrasound;
RESOLUTION COMPUTED-TOMOGRAPHY;
PULMONARY-FIBROSIS;
RHEUMATOID-ARTHRITIS;
SYSTEMIC-SCLEROSIS;
B-LINES;
CLASSIFICATION;
SONOGRAPHY;
DIAGNOSIS;
CT;
D O I:
10.1002/jum.15790
中图分类号:
O42 [声学];
学科分类号:
070206 ;
082403 ;
摘要:
Objectives In this study, we sought to assess the validity of lung ultrasound (LUS) during the follow-up of patients with a wide spectrum of interstitial lung diseases (ILDs). Methods Twenty-four patients (13 males, 11 females; mean age +/- SD, 65.4 +/- 14.3 years; age range, 40-84 years) with a diagnosis of ILDs who were admitted to the Interstitial Lung Disease Unit were prospectively enrolled. Patients were examined with a 56-lung intercostal space LUS protocol in lateral decubitus position, at baseline, 6-months, and 1-year. The LUS score was defined as the sum of B-lines counted in each intercostal space. All patients underwent complete pulmonary function tests at baseline and follow-up time-points. High-resolution computed tomography (HRCT) was performed at baseline and during follow-up, according to personalized patients' needs. All HRCT studies were graded according to the Warrick scoring system (WS). Results Pooled data analysis showed a significant correlation between WS and LUS scores (P < .001). For separate time-point analysis, a significant correlation between LUS scores and WS was found at baseline (P < .001) and 1 year (P = .005). LUS scores negatively correlated with alveolar volume (VA) (P < .046) and diffusing capacity for carbon monoxide (DLCO) (P < .001) at 6 months and with transfer coefficient of the lung for carbon monoxide (KCO) (P < .031) and DLCO (P = .002) at 12-months. A multivariate regression model showed DLCO to be an independent predictor of LUS score at 1 year (P = .026). Conclusions Our results highlight the validity and potential applicability of LUS for disease monitoring in a wide spectrum of ILDs.
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页码:1077 / 1084
页数:8
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