On the Detection of Propofol in Exhaled Air by MOS Gas Sensors

被引：1
|
作者：
Bur, Christian [1 ]
Lensch, Henrik [1 ]
Maurer, Felix [2 ,3 ]
Kreuer, Sascha [2 ,3 ]
Schuetze, Andreas [1 ]
机构：
[1] Saarland Univ, Lab Measurement Technol, Campus A5 1, D-66123 Saarbrucken, Germany
[2] Saarland Univ Med Ctr, CBR Ctr Breath Res, Dept Anaesthesiol Intens Care & Pain Therapy, D-66424 Homburg, Germany
[3] Saarland Univ, Fac Med, D-66424 Homburg, Germany
来源：
TM-TECHNISCHES MESSEN | 2022年 / 89卷 / s1期
关键词：
propofol; MOS sensor; temperature cycled operation; breath analysis; DISEASE DIAGNOSIS; BREATH ANALYSIS;
D O I：
10.1515/teme-2022-0060
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
Bedside and non-invasive measurement of drugs in exhaled air within short time frames or even online could have a high therapeutic relevance. In this study, a commercially available metal oxide semiconductor (MOS) gas sensor, i.e. ENS160 from ScioSense, in temperature cycled operation (TCO) is studied for quantification of the intravenous anesthetic propofol. Propofol was chosen because a correlation of the plasma concentration to the concentration in exhaled air was already proven. A partial least regression model (PLSR) was built for quantification of propofol while suppressing the influence of humidity and ethanol as a main interferent. The root mean squared error (RMSE) of validation was as low as 4 ppb for a concentration range of 0 ppb to 40 ppb. The results suggest the usage of MOS sensor for drug monitoring.
引用
收藏
页码：66 / 71
页数：6
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