Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body

被引：91

作者：

Duronio, Robert J. ^{[1
,2
,3
,4
]}

Marzluff, William F. ^{[1
,3
,4
,5
]}

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Integrat Program Biol & Genome Sci, CB 7100, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[5] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

来源：

RNA BIOLOGY | 2017年 / 14卷 / 06期

关键词：

Cell cycle; Drosophila; histone genes; mRNA processing; nuclear body; PRE-MESSENGER-RNA; SMALL NUCLEAR-RNA; XENOPUS GERMINAL VESICLE; DROSOPHILA U7 SNRNP; PROCESSING IN-VIVO; S-PHASE ENTRY; CAJAL BODY; POLYADENYLATION FACTORS; E/CDK2; SUBSTRATE; POLYMERASE-II;

D O I：

10.1080/15476286.2016.1265198

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metazoan replication-dependent (RD) histone genes encode the only known cellular mRNAs that are not polyadenylated. These mRNAs end instead in a conserved stem-loop, which is formed by an endonucleolytic cleavage of the pre-mRNA. The genes for all 5 histone proteins are clustered in all metazoans and coordinately regulated with high levels of expression during S phase. Production of histone mRNAs occurs in a nuclear body called the Histone Locus Body (HLB), a subdomain of the nucleus defined by a concentration of factors necessary for histone gene transcription and pre-mRNA processing. These factors include the scaffolding protein NPAT, essential for histone gene transcription, and FLASH and U7 snRNP, both essential for histone pre-mRNA processing. Histone gene expression is activated by Cyclin E/Cdk2-mediated phosphorylation of NPAT at the G1-S transition. The concentration of factors within the HLB couples transcription with pre-mRNA processing, enhancing the efficiency of histone mRNA biosynthesis.

引用

页码：726 / 738

页数：13

共 50 条

[11] PARALLEL PATHWAYS OF CELL CYCLE-REGULATED GENE-EXPRESSION
LOWNDES, NF
JOHNSTON, LH
TRENDS IN GENETICS, 1992, 8 (03) : 79 - 81
[12] Regulation of histone gene expression during the cell cycle
Meshi, T
Taoka, K
Iwabuchi, M
PLANT MOLECULAR BIOLOGY, 2000, 43 (5-6) : 643 - 657
[13] Regulation of histone gene expression during the cell cycle
Tetsuo Meshi
Ken-ichiro Taoka
Masaki Iwabuchi
Plant Molecular Biology, 2000, 43 : 643 - 657
[14] High-resolution timing of cell cycle-regulated gene expression
Rowicka, Maga
Kudlicki, Andrzej
Tu, Benjamin P.
Otwinowski, Zbyszek
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (43) : 16892 - 16897
[15] Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression
Zanier, K
Luyten, I
Crombie, C
Müller, B
Schümperli, D
Linge, JP
Nilges, M
Sattler, M
RNA, 2002, 8 (01) : 29 - 46
[16] CELL-CYCLE-REGULATED HISTONE GENE-EXPRESSION IN SYNCHRONIZED PLANT-CELLS
REICHHELD, JP
SONOBE, S
CLEMENT, B
CHAUBET, N
GIGOT, C
PLANT JOURNAL, 1995, 7 (02): : 245 - 252
[17] Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein
Richardson, RT
Batova, IN
Widgren, EE
Zheng, LX
Whitfield, M
Marzluff, WF
O'Rand, MG
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (39) : 30378 - 30386
[18] Histone gene expression during the cell cycle in Trypanosoma cruzi
Sabaj, V
Aslund, L
Pettersson, U
Galanti, N
JOURNAL OF CELLULAR BIOCHEMISTRY, 2001, 80 (04) : 617 - 624
[19] CELL-CYCLE REGULATION OF HISTONE GENE-EXPRESSION
SCHUMPERLI, D
CELL, 1986, 45 (04) : 471 - 472
[20] CELL-CYCLE REGULATION OF HISTONE GENE-EXPRESSION
LUSCHER, B
STAUBER, C
SCHUMPERLI, D
EXPERIENTIA, 1985, 41 (06): : 806 - 806

← 1 2 3 4 5 →